慢性充血性心力衰竭患者血清基质金属蛋白酶的液相芯片检测  

Detection of serum matrix metalloproteinase in patients of chronic congestive heart failure with liquichip

作　　者：邓元江[1] 梁伟雄[2] 陈云波[2] 程淑意[2] 王奇[2] 陈海燕[1] 赵益业[1] 江俊珊[1] 张卫[3] 

机构地区：[1]广东省中医院心脏中心,广州510120 [2]广州中医药大学DME中心,广州510405 [3]广东药学院附属第一医院心内科,广州510080

出　　处：《广东医学》2006年第3期335-336,共2页Guangdong Medical Journal

基　　金：*国家"863"计划子课题(编号:2002AA2Z341B);中国博士后科学基金(编号:2005038175);高等学校博士学科点专项科研基金(编号:20050572008)

摘　　要：目的探讨慢性充血性心力衰竭(CHF)患者血清基质金属蛋白酶(MMPs)的变化。方法CHF患者15例,正常对照组15例,采用Luminex液相芯片分析平台测定血清MMP-3及MMP-9的含量。结果CHF患者血清MMP-3,MMP-9的含量比正常对照组明显增加(P<0.05)。结论CHF患者血清MMP-3,MMP-9含量增高,与心室重构有关。Objective To study the change of serum matrix metallopreteinase in patients of chronic congestive heart failure （CHF） with Liquichip. Methods MMP-3 and MMP-9 were measured in sere of 15 cases of CHF patients and 15 normal controls with Luminex liquichip. Results Serum MMP-3 and MMP-9 in patients of CHF were significandy higher than normal control （P 〈 0.05）. Conclusion The concentrations of serum MMP-3 and MMP-9 in patients of CHF is higher and is associated with ventricular remodeling.

关 键 词：充血性心力衰竭 心室重构 基质金属蛋白酶 液相芯片 

分 类 号：R563.1[医药卫生—呼吸系统] R259.416.1[医药卫生—内科学]