机体对纳米粒子的排泄作用及其可能途径  

Study on Excretion Pathways of Nano-Particles

作　　者：孙岚[1] 杨留中[1] 张英鸽[1] 

机构地区：[1]军事医学科学院毒物药物研究所,北京100850

出　　处：《中国药学杂志》2006年第5期363-367,共5页Chinese Pharmaceutical Journal

基　　金：国家自然科学基金资助项目(90406024-7);军队十五科研基金重点(01Z024)

摘　　要：目的探讨纳米粒子是否能从体内排出。方法将纳米活性炭(ACNP)或印度墨水经静脉注入动物体内,在注射后不同时间收取胆汁和尿液,在透射电镜下观察有无纳米粒子的排出。在停药后不同时间取动物肝脏、肠和肾脏等脏器组织进行光镜病理检查,提供纳米粒子是否可以从这些器官排出的佐证。结果经静脉注射的纳米粒子可随血液分布到肝脏、肠和肾脏等脏器组织中,胆汁及尿液中含有大量高密度粒子。结论纳米粒子可能随胆汁,尿液排出体外;肺,小肠,大肠可能是纳米粒子排泄的另外途径。OBJECTIVE To explore, the possible excretion pathways of nano-particles.METHODS Biliary and urinary samples were collected and prepared for transmission electron microscopy observation after activated carbon nano-particles （ACNP） and Indian ink （Ⅱ） were injected into rabit＇s vein. Meanwhile,liver, intestine and kidney were taken out and pathological sections were prepared for light microscopy observation.RESUTS The intravenous nano-partieles had wide distribution in animalis-liver, intestine and kidney and there were many nano-particles in bile and urine. CONCLUSION Nano-particales may be excreted through bile and urine. Lung, small intestine and large intestine may also be excretion pathways.

关 键 词：纳米粒子 纳米活性炭 印度墨水 

分 类 号：R965.3[医药卫生—药理学]