桂麻合方对哮喘豚鼠引喘潜伏期及肺组织病理变化的影响。  

EFFECTS OF GUI-MA COMPOUND ON THE LATENT PERIOD OF INDUCING ASTHMA AND THE PATHOLOGICAL CHANGES OF LUNG TISSUE OF GUINEA PIG

作　　者：刘小刚[1] 贾春华[2] 郭玉成[1] 李静华[1] 李小军[1] 庞宗然[1] 

机构地区：[1]承德医学院,河北承德067000 [2]北京中医药大学

出　　处：《承德医学院学报》2006年第1期3-6,共4页Journal of Chengde Medical University

基　　金：国家自然科学基金项目(30371723;30572298)

摘　　要：目的:探讨桂麻合方对哮喘豚鼠引喘潜伏期及肺组织病理变化的影响。方法:建立豚鼠哮喘模型,设立正常对照、哮喘模型、桂枝汤、麻黄汤、桂麻各半汤(先煎后合)、桂麻各半汤(先合后煎)、桂二麻一汤(先煎后合)、桂二麻一汤(先合后煎)共八组,分别测定豚鼠引喘潜伏期并在光镜下观察豚鼠肺组织的病理学改变。结果:桂麻合方六组皆能延长哮喘豚鼠的引喘潜伏期;且桂麻合方六组均可改善哮喘豚鼠肺组织的病理改变,但六组的作用强度不尽相同。结论:桂麻合方能减轻过敏性哮喘豚鼠肺内局部炎性反应,从而缓解哮喘发作。提示桂麻合方治疗哮喘可能是通过延长哮喘发作的潜伏期,减少肺组织炎性浸润而实现的。Objective： To investigate the effects of gui-ma compound on the latent period of inducing asthma and the pathological changes of lung tissue of guinea pig. Methods： The asthma animal models were established at first and the guinea pigs were divided into 8 groups at random, and each group had 8 guinea pigs： normal control group, asthma model group, guizhi decoction group, mahuang decoction group, gui-ma decoction group（1-1, cooked before mixed）, gui-ma decoction group（1-1, mixed before cooked）, gui-ma decoction group（2-1, cooked before mixed） amd gui-ma decoction group（2-1, mixed before cooked）. The latent period of inducing asthma was detected and the pathological changes of lung tissue were observed under light microscopy. Results： The latent period of allergic asthma attack could be prolonged by the 6 gui-ma compound, and the inflammatory infiltration of lung tissue was also relieved in the 6 gui-ma compound groups, but the effective intensity in the 6 gui-ma compound groups was different. Conclusions. Gui-ma compound can relieve the inflammatory reaction in lung tissue, therefore relief asthmatic attack. The possible mechanisms maybe gui-ma compound can prolong the latent period of asthma and relieve inflammatory infiltration in lung tissue.

关 键 词：过敏性哮喘 桂麻合方 引喘潜伏期 肺 豚鼠 

分 类 号：R289.3[医药卫生—方剂学]