长期血透和促红素对尿毒症患者心血管及微循环的影响  

Effects of Maintenance Hemodialysis and rhEPO on Cardiovascular Function and Microcirculation in Uremic Patients

作　　者：朱汉威[1] 温莉萍[1] 曹钟兴[1] 宁琳[1] 冯菡芳[1] 王增金 

机构地区：[1]上海第二医科大学附属新华医院肾脏内科,上海市杨浦区平凉街道医院

出　　处：《上海第二医科大学学报》1996年第2期110-112,共3页Acta Universitatis Medicinalis Secondae Shanghai

摘　　要：用心血管功能测定仪研究了３０例慢性肾衰患者血透不同阶段的心功能情况及促红细胞生长素对其心血管功能和微循环的影响。结果：２０例血透时间小于４月尿毒症患者的心搏出量、心输出量和心脏指数均低于１０例血透１～３年的患者。所有患者微循环半更新率、微循环半更新时间均比正常人高，而血管顺度比正常人低。１０例血透患者用促红细胞生成素治疗后，心搏出量、心输出量、心脏指数、微循环半更新率降低，而血管外周阻力、微循环半更新时间增加。提示长期透析能使心功能改善；促红素能改善患者高动力循环。This study was designed to investigate the effects of different hemodialysis stages and recombinant human erythropoietin (rhEPO) treatment on cardiovascular function and microcirculation. Hemodialysis was examined in 30 patients with chronic renal failure,using a cardiovascular function detecting instrument.The results showed that stroke volume (SV),cardiac output (CO) and cardiac index (CI) in 20 cases who had been treated with hemodialysis for less than 4 months (G_1) were significantly lower than in the other 10 cases who had hemodialysis more than 1 year (G_2).It was found that in all the patients the half-turnover rate of microcirculation (MHR)was higher and the half-turnover time of microcirculation (MHT) was shorter than normal controls. Vascular compliance was decreased in all patients. SV,CO,CI and MHR were decreased,whereas TPR and MHT were inceased in G_2 patients after rhEPO treatment for two months.

关 键 词：血液透析 微循环 尿毒症 促红细胞生成素 

分 类 号：R695.05[医药卫生—泌尿科学]