碘催化合成三乙基膦酰乙酸酯  

Synthesis of Triethyl Phosphonoacetate Esters Catalyzed by Iodine

作　　者：蔡小华[1] 刘志华[1] 杨志学[1] 

机构地区：[1]怀化医学高等专科学校药学系,湖南怀化418000

出　　处：《化学研究》2006年第1期41-43,共3页Chemical Research

基　　金：湖南省教育厅科研资助项目(02C050)

摘　　要：首次报道了碘对M ichaelArbuzov重排反应的催化作用.以亚磷酸三乙酯与2-卤代乙酸乙酯为原料,碘作催化剂,反应温度80℃,反应时间2 h,三乙基膦酰乙酸酯的产率达到90%-98%.It is reported firstly that iodine is a very good catalyst for the Michael Arbuzov rearrangement. Triethyl phosphonocetate esters were synthesized from triethyl phosphite and ethyl 2-haloacetate using iodine as catalyst in 90% -98 % yield under lower temperature and shorter reaction time.

关 键 词：MICHAEL Arbuzov重排反应 三乙基膦酰乙酸酯 亚磷酸三乙酯 碘 催化 

分 类 号：O627.5[理学—有机化学]