微粒子酶免疫法测定他可莫司的血药浓度  

Determination of whole blood concentration of tacrolimus drug with MEIA

作　　者：王利新[1] 张建荣[1] 杨宝珍[1] 王志伟[1] 

机构地区：[1]宁夏医学院附属医院,宁夏银川750004

出　　处：《宁夏医学杂志》2006年第3期168-169,共2页Ningxia Medical Journal

摘　　要：目的为临床肝移植患者抗移植排斥反应药物的合理应用提供参考。方法采用微粒子酶免疫法(MEIA)对肝移植患者进行他可莫司血药浓度测定,并对结果进行分析。结果为6例肝移植患者检测他可莫司血药浓度77例次,质控结果均在有效范围内。肝移植术后他可莫司全血血药浓度在10-20μg/L范围内的占30.6%。结论为用药安全有效,应对肝移植患者监测FK506血药浓度,实行个体化给药。Objective To give some information for rationally administrating oral FKS06 to liver wamplant patients in clinical. Methods The whole blood concentration of FK506 on 6 liver transplant patients was determined by mieo - particle enzyme immavnoassy （MEIA）, the results and therapeutic effect were studied. Results There were 77 cases in 6 liver transplant patients detemained FK506 concentration, the quality control of MEIA was in effective level, The whole blood with effective level（ 10- 20μg/L） were accounted for 30.6 %. Conclusion To be safe and effective for clinical use, it is important for liver transplant patients to monitor whole blood concentrations of FK506 with individualized drug administration.

关 键 词：他可莫司 血药浓度 微粒子酶免疫法 

分 类 号：R96[医药卫生—药理学]