FOXL2对IVF周期卵巢反应性的影响  

Ovarian response to FOXL2 in IVF.

作　　者：曲中玉[1] 陈子江[1] 

机构地区：[1]山东大学山东省立医院生殖医学中心,济南250021

出　　处：《现代妇产科进展》2006年第2期128-130,共3页Progress in Obstetrics and Gynecology

基　　金：山东省十大示范工程提高新生儿出生质量综合技术研究基金资助

摘　　要：目的：探讨FOXL2在人卵巢黄素化颗粒细胞表达与IVF周期超促排卵过程中卵巢反应性的关系。方法：采用半定量逆转录聚合酶链反应（RT—PCR）技术测定84例体外受精一胚胎移植（IVF—ET）周期中卵巢黄素化颗粒细胞FOXL2 mRNA的表达。结果：卵巢低反应型（卵泡数≤3个）FOXL2 mRNA表达量显著低于中反应型（卵泡数4～13个）和高反应型（卵泡数≥14个）（P〈0．05）；FOXL2表达强度与血清基础FSH呈负相关（r=-0．46，P〈0．05）。结论：卵巢颗粒细胞上FOXL2水平影响体外受精-胚胎移植过程中卵巢对促性腺激素的反应。卵巢颗粒细胞上FOXL2表达水平与卵巢储备功能有关，卵巢功能下降可能与卵巢颗粒细胞上FOXL2表达水平降低有关。Objective：To explore the relationship between levels of FOXL2 in human granulosa cells and ovarian response to controlled ovarian hyperstimulation. Methods： The FOXL2 mRNA in human granulosa cells was determined by semi-quantitative RT-PCR. Results ：The expression of FOXL2 on granulosa cell in poor responders （follicles ≤3 ） had significantly lower than those of normal responders （ follicles 4 - 13 ） and high responders （ follicles ≥ 14）. The expression of FOXL2 had negative correlation with FSH （ r = - 0.46 ,P 〈 0.05 ）. Conclusion：The expression of FOXL2 influences ovarian response to gonadotropin hormone. FOXL2 is possibly an effective marker of ovarian reverse, a reduced FOXL2 expression of granulosa cells may be involved in decreased ovarian function.

关 键 词：FOXL2 控制性超排卵 卵巢反应性 体外受精 胚胎移植 

分 类 号：Q492.5[生物学—生理学]