定量组织速度成像评价阿霉素性心肌病心脏收缩功能的研究  

Evaluation of cardiac systolic function of adriamycin cardiomyopathy by quantitive tissue velocity imaging: an animal study

作　　者：陈孝义[1] 郭瑞强[1] 郝力丹[1] 黄从新[2] 

机构地区：[1]武汉大学人民医院超声影像科,430060 [2]武汉大学人民医院心内科,430060

出　　处：《中华超声影像学杂志》2006年第3期220-222,共3页Chinese Journal of Ultrasonography

摘　　要：目的研究定量组织速度成像评价阿霉素性心肌病心脏收缩功能的价值。方法制作阿霉素性心肌病模型兔7只,随机选取5只健康兔作为对照组,应用定量组织速度成像(QTVI)检测心尖四腔观室间隔基底段心肌最大收缩速度(VIVS)、位移(DIVS)、应变率(SRIVS)、应变(IδVS),胸骨旁长轴观左室后壁基底段心肌最大收缩速度(VLVPW)、位移(DLVPW);以心电图和二尖瓣与主动脉瓣口脉冲血流频谱标记心动周期,测量左室射血前间期(PEP)、左室射血前间期与射血时间比值(PEP/ET)。结果病变组VIVS、DIVS、SRIVS、δIVS和VLVPW、DLVPW均显著减低,PEP延长,PEP/ET增大;而心脏射血分数在两组间差异无统计学意义。结论反映心肌收缩过程的QTVI心功能指标,在阿霉素所致心肌病变时比EF更早发生异常改变,QTVI可作为早期诊断和评价阿霉素性心肌病更好的检查方法。Objective To explore the value of quantitive tissue velocity imaging （QTVI） in assessing the systolic myocardial function of adriamycin cardiomyopathy. Methods Conventional echocardiography and QTVI were performed in 7 rabbit models with adriamycin cardiomyopathy and 5 health rabbits as control. The basic segments of interventricular septum of apical 4-chamber view and left ventricular post wall of parastenal left ventricular long axis view were sampled to measure maximal velocity（VIVS, VLVPW ）, displaeement（DIVS, DLVPW ）, strain rate（SRIVS） and strain（δIVS） in systole. Pre-eject period（PEP） and ratio of pre-eject period and eject time （PEP/ET） were measured with electrocardiography and Doppler spectrums of mitrial and aortic orifices. Results Compared with control, VIVS, DIVS, SRIVS, δIVS and VLVPW, DLVPW decreased（ P 〈0. 05）, PEP prolonged and PEP/ ET increased in group adriamycin. There was no difference in left ventricular eject fraction （EF） between both the groups（ P 〉0.05）. Conclusions The indices of QTVI are more sensitive to evaluate systolic function changes than EF,and QTVI may be an optimal method to early diagnose and access of adriamycin cardiomyopathy.

关 键 词：超声心动描记术 心肌疾病 多柔比星 心室功能 左 

分 类 号：R542.2[医药卫生—心血管疾病]