急性心肌梗死患者血清NO浓度的变化与心肌缺血预适应的关系  

The study on the effect of nitric oxide in acute myocardial infarction- related ischemic preconditioning

作　　者：吴汉宁[1] 赵廷利 张娟娟[1] 戴兴歧 

机构地区：[1]山东省泰安铁路医院,271000

出　　处：《中国现代医药杂志》2005年第6期20-21,共2页Modern Medicine Journal of China

摘　　要：目的观察急性心肌梗死(AMI)患者血清一氧化氮(NO)浓度的变化与心肌缺血预适应的关系。方法将82例AMI患者分成心绞痛组(AP)48例和无心绞痛组(Non-AP)34例,测定患者血清CPK及其同功酶CK-MB、肌钙蛋白I(CTnI),并用硝酸还原酶法经比色法测定血清一氧化氮(NO)水平。结果心肌梗死前有心绞痛者的CPK、CK-MB、CTnI较低,而NO水平较高,与心肌梗死前无心绞痛的患者比较有显著性差异(P<0.05)。结论心绞痛对AMI的心肌损害有明显保护作用。而NO在缺血预适应心肌保护中起重要作用。Objective To evaluate the role of NO in pathogensis of ischemic preconditioning in the patients with acute myocardial infarction. Methods The levels of plasma NO were measured by chemicolorimetric analysis in 82 patients with different groups （A and B group） of acute myocardial infarction （AMI）, and measured the levels of CPK, CPK-MB, TnI. Results The levels of serum NO in angina （A group） of AMI were significantly higher than those in Non-angina of AMI （B groups）, the levels of CPK, CK-MB, TnI in A group were significantly lower than those of B group in the patients of acute myocardial infarction; Positive correlation between NO were found in acute myocardial infarction. Conclusions NO can be the protecting to myocardial ischemic injury, but those might play a role in pathogenesis of ischemic preconditioning.

关 键 词：心绞痛 心肌梗死 一氧化氮 缺血预适应 

分 类 号：R542.22[医药卫生—心血管疾病] R473.5[医药卫生—内科学]