克拉霉素胃漂浮小丸的制备  

Preparation of clarithromycin-containing floating pellets in stomach

作　　者：郑建华[1] 包德才[1,2] 刘朝武[1] 赵燕军[1] 马小军[1] 

机构地区：[1]中国科学院大连化学物理研究所,中国科学院研究生院 [2]渤海大学化学与化工学院,辽宁锦州121000

出　　处：《化工学报》2006年第2期363-366,共4页CIESC Journal

基　　金：中国科学院知识创新工程领域前沿项目(K2002A2);国家自然科学基金项目(20176056).~~

摘　　要：Two types of floating pellets in stomach were prepared. The first one: floating alginate pellets containing ethylcellulose and clarithromycin (AE)were pellets with dispersed ethylcellulose in the alginate gel matrix. The second one:ethylcellulose microspheres containing clarithromycin (Em) were first prepared by the emulsion solvent diffusion method, and then alginate pellets containing ethylcellulose microspheres (AEm) were prepared. The effects of processing parameters on morphology, size distribution, drug loading, in vitro drug release profiles, in vitro floating property of pellets were investigated. The results showed that about 80% of drug incorporated in AE was released at 2 h, while AEm with moderate drug content had sustained drug release property. The accumulative drug-release percent of AEm in vitro at 6 h were 65.9%—78.8%, and AEm could float in acetate buffer solution for more than 8 h.Two types of floating pellets in stomach were prepared. The first one： floating alginate pellets containing ethylcellulose and clarithromycin （AE） were pellets with dispersed ethylcellulose in the alginate gel matrix. The second one： ethylcellulose microspheres containing clarithromycin （Em） were first prepared by the emulsion solvent diffusion method, and then alginate pellets containing ethylcellulose microspheres （AEm） were prepared. The effects of processing parameters on morphology, size distribution, drug loading, in vitro drug release profiles, in vitro floating property of pellets were investigated. The results showed that about 80% of drug incorporated in AE was released at 2 h, while AEm with moderate drug content had sustained drug release property. The accumulative drug-release percent of AEm in vitro at 6 h were 65.9%--78.8%, and AEm could float in acetate buffer solution for more than 8 h.

关 键 词：克拉霉素 胃漂浮小丸 海藻酸钠 乙基纤维素 幽门螺旋杆菌 

分 类 号：R318.08[医药卫生—生物医学工程]