丹酚酸B、丹参酮ⅡA对动脉粥样硬化家兔血清一氧化氮及甘油三酯的影响  

The influence of salvianolic acid B and tanshinoneⅡA on the nitric oxide and triglyceride in sera of atherosclerosis rabbits

作　　者：吕炳强[1] 范英昌[1] 孙连胜[2] 

机构地区：[1]天津中医学院,300193 [2]天津市塘沽区杭州道医院,300354

出　　处：《天津中医学院学报》2006年第1期32-34,共3页Journal of Tianjin College of Traditional Chinese Medicine

基　　金：天津市自然科学基金项目(023611611)。

摘　　要：[目的]观察丹参水溶性成分丹酚酸B和脂溶性成分丹参酮ⅡA对家兔动脉粥样硬化模型血清一氧化氮(NO)及甘油三酯(TG)浓度的影响,以寻找其作用耙点。[方法]复制家兔动脉粥样硬化模型,分别用放射性免疫方法和比色法检测血清NO和TG浓度,观察丹酚酸B和丹参酮ⅡA抗动脉粥样硬化的作用异同。[结果]丹酚酸B和丹参酮ⅡA都能增加动脉粥样硬化家兔血清NO浓度,降低血清TG浓度。但升高NO的作用丹参酮ⅡA优于丹酚酸B;降低TG作用丹酚酸B优于丹参酮ⅡA。[结论]丹参水溶性成分与脂溶性成分都能调节血清NO及TG浓度而达到抗动脉粥样硬化的作用,但具体作用机制有所不同。[Objective] To study the influence of water-soluble active principle （salvianolic acid B） and fat-soluble active principle （tanshinone Ⅱ A） on the level of nitric oxide （NO） and triglyc- eride （TG） in sera of atherosclerosis rabbits. [Methods] Atherosclerosis was initiated in rabbits by feeding cholesterol and oil.The influence of salvianolic acid B and tanshinone ⅡA on sera NO and TG were observed by radio immunity and GPO-PAP. [Results] Both of the salvianolic acid B and the tanshinone Ⅱ A could markedly decrease the level of TG and significantly increase the NO; but the tanshinone Ⅱ A was significantly better than the salvianolic acid B on NO, the salvianolic acid B was better significantly better than the tanshinone Ⅱ A on TG. [Conclusion] The salvianolic acid B and tanshinone Ⅱ A both could inhit atherogenesis of hyperlipid-fed rabbits by modulate the NO and TG, but the mechanism is not entire the same.

关 键 词：丹参 丹酚酸B 丹参酮ⅡA 动脉粥样硬化 一氧化氮 甘油三酯 

分 类 号：R259.435[医药卫生—中西医结合]