七叶皂苷及其中4种组分的抗炎作用研究  

Effects ofEscin and Its Four Elements on anti-inflammation

作　　者：齐艳[1] 张厚利[1] 杨彤[1] 

机构地区：[1]大连医科大学药学院,辽宁大连116027

出　　处：《中医药学刊》2006年第3期534-536,共3页Study Journal of Traditional Chinese Medicine

摘　　要：目的:研究七叶皂苷及其中A、B、C、D组分的抗炎活性并初步探讨其作用机制。方法:用大鼠双侧腹股沟部接种无菌棉球方法制备慢性炎症模型,分为阳性对照、阴性对照、七叶皂苷、A、B、C及D组分组,分别观察受试药物对上述模型的作用。结果:七叶皂苷及其中4个组分(0.5、1.0、2.0mg/kg,iv)对大鼠棉球肉芽肿均有明显的抑制作用,并显示出明显的剂量依赖性。结论:七叶皂苷及A、B、C、D组分均具有抗炎作用,抗炎作用机制可能与肾上腺皮质激素有关。Objective ： To investigate the inhibition effects on the cotton granuloma and its possible mechanism of the elements of escin A,B,C,D that isolated from escin. Methods ： Sterilized cotton 50mg was inoculated in the groin of rats. Drugs were injected into tail vein daffy and lasted for 7 days. At the 8th day, the granulomas had been isolated and then baked for 12 hours at 70℃. Then inhibition rates were calculated. At the same time, suprarenal glands and thymus gland of the rats were isolated and weighted. Results ： Escin and its elements A、B、C、D can inhibit rat cotton granuloma obviously and the inhibition rates are dose -depended. Conclusion ： All Escin and its elements A,B,C,D can inhibit inflammation in a dose -depended way. The mechanism of anti - inflammation is likely related to the adrenal cortical hormone

关 键 词：七叶皂苷 七叶皂苷A B C D 抗炎作用 组分 

分 类 号：R284[医药卫生—中药学]