3-醛基吲哚-5-甲酸乙酯的合成  

Synthesis of ethyl 3-formylindole-5-carboxylate

作　　者：葛裕华[1] 吴亚明[1] 薛忠俊[1] 

机构地区：[1]东南大学化学化工系,江苏南京210096

出　　处：《化学试剂》2006年第2期123-123,125,共2页Chemical Reagents

摘　　要：报道了以3-甲基-4-硝基苯甲酸为原料的标题化合物的合成方法,总收率达63%。其结构经1HNMRI、R和MS得到确证。The synthesis method of a new compound ethyl 3-formylindole-5-carboxylate（ 1 ） has been reported. The intermediate ethyl indole-5-carboxylate was obtained from 3-methyl-4-nitrobenzoic acid as raw material by esterification with EtOH, condensation with DMFDEA and piperidine, reduction with Fe/HAc. Then it was reacted with POCI3/DMF through Vilsmeier-Hacck reaction, the target product 1 was synthesized with a total yield of 63 % .The structure of 1 was confirmed by ^1HNMR, IR and MS.

关 键 词：3-醛基吲哚-5-甲酸乙酯 吲哚-5-甲酸乙酯 合成 

分 类 号：O625[理学—有机化学]