高效液相色谱手性固定相拆分手性化合物  

Chiral separation of racemic compounds on chiral column by HPLC

作　　者：刘峻[1] 韩小茜[1] 李军[1] 赵立峰[1] 王夙[1] 

机构地区：[1]兰州交通大学化学与生物工程学院,甘肃兰州730070

出　　处：《化学试剂》2006年第3期172-174,共3页Chemical Reagents

基　　金：甘肃省教育厅资助项目(0316B-03);兰州交通大学"青蓝人才工程资助计划"资助项目

摘　　要：在纤维素衍生物手性固定相上直接拆分了3种手性化合物,并初步探讨了流动相组分———醇的种类及结构对拆分手性化合物的影响。The chiral separation of three pairs of racemic compounds were directly performed on polysaccharide-based chiral stationary phase. The influence of the mobile phase modifier of alcoholic type, the mobile phases and the structures of chiral racemic compounds on the chiral separation and retention were investigated. It was found that the structure and alcohol concentration in mobile phase and the subtle structural differences in the racemic compound could have an effect on the enantiometric separation and retention.

关 键 词：高效液相色谱 手性固定相 手性化合物 手性拆分 

分 类 号：O657.7[理学—分析化学]