间歇白细胞去除法治疗紫癜性肾炎疗效观察  

Therapeutic Effects Observation of Intermittent Eliminating White Blood Cells in Children with Anaphylatoid Purpura Nephritis

作　　者：伏昱璇[1] 陈若华[1] 蒋瑾瑾[1] 

机构地区：[1]第二军医大学附属长海医院儿科,上海200433

出　　处：《实用儿科临床杂志》2006年第5期295-296,共2页Journal of Applied Clinical Pediatrics

摘　　要：目的 探讨应用激素的基础上，加用间歇性白细胞去除法与加用免疫抑制剂冲击疗法治疗重症紫癜性肾炎的疗效。方法 选择12例重症紫癜性肾炎患儿分为对照组5例和观察组7例，两组均在激素冲击治疗无效基础上，观察组加用间歇件白细胞去除法（5mL／kg，1～2次/周），对照组加用免疫抑制剂环磷酰胺（CTX）0.8～1．0g／m^2．或甲氨蝶呤（MTX）8～10g／m^2治疗。结果两组治疗效果无显著差异（X^2=0．114 P〉0．1）．观察组均无不良反应，对照组均有恶心、呕吐，1例白细胞下降。结论 采用间歇性白细胞去除法治疗可避免免疫抑制剂的不良反应，取得较好治疗效果。Objective To study the different effects between intermittent eliminating white blood cells and immunosuppressive a gents pulse therapy in children＇s anaphylatoid purpura nephritis on the base of hormone＇s treatment. Methods Twelve cases of anaphylatoid purpura nephritis were enrolled in the study and divided into 2 groups. After failure in the hormone＇s treatment, the observation group was applied with intermittent eliminating white blood cells（5mL/kg, 1-2 time.s/week）, and the control group was treated with inmunosupprssive agents[cyclophosphamide（CTX） 0.8 1.0 g/m^2 ,or methotrexate（MTX） 8-10g/m^2] .Results There were no significant differences between the 2 groups. The observation group had no obvious side effects, but the control group all had different side effects. Conclusion The treatment of intermittent eliminating white blood cells can have better effects without the side effect re suiting from agents.

关 键 词：肾炎 紫癜性 间歇性白细胞去除法 免疫抑制剂 

分 类 号：R726.9[医药卫生—儿科]