大鼠松果体褪黑素含量增龄性变化的研究  

A study on the melatonin content of the pineal gland of rats associated with increasing age

作　　者：朱俊德[1] 王景传[1] 许庭良[2] 龚明 

机构地区：[1]贵阳医学院解剖学教研室,贵阳55004 [2]贵阳医学院组织胚胎学教研室,贵阳55004 [3]贵州益佰制药有限公司药研所,贵阳55002

出　　处：《解剖学研究》2006年第1期26-29,共4页Anatomy Research

基　　金：贵阳医学院青年教师基金资助项目(K2003-7)

摘　　要：目的探讨大鼠松果体褪黑素含量的增龄性变化规律。方法32只健康SD大鼠随机分为1～2月龄组、4～5月龄组、11～12月龄组和≥24月龄组4个年龄组。每组8只,雌雄各半。用高效液相色谱测定松果体褪黑素含量。结果1～2月龄组褪黑素含量为1.492±0.158,4～5月龄组为1.088±0.059,11～12月龄组为0.233±0.101,≥24月龄组为0.127±0.037,各组间差异有统计学意义(P<0.01)。结论大鼠松果体随增龄而出现褪黑素含量下降,这可能是导致机体发生衰老的原因之一。Objective To explore the change of melatonin content of the pineal gland with aging in rats. Methods Thirty-two healthy Sprague-Dawley rats were randomly divided into four groups： 1-2 months group, 4-5 months group, 11-12 months group and above 24 months group. There were 8 rats in every group, and the number of male and that of female rats are equal. The melatonin content of the pineal gland was determined by the high-performance liquid chromatography. Results The melatonin content of pineal gland in every group was as following： 1-2 months group was 1.492±0.158, 4-5 months group was 1.088±0.059, 11-12 months group was 0.233±0.101, and above 24 months group was 0.127±0.037. There were statistical significance between each group. Conclusion The melatonin content decreases with aging. The functional changes of pineal gland would be a cause of aging.

关 键 词：松果体 褪黑素 增龄性变化 大鼠 

分 类 号：R33[医药卫生—人体生理学]