用环瑚精分离取代四氢-β-咔啉类手性化合物  

Chiral Separation of Tetrahydro-β-carboline Compounds by Capillary Zone Electrophoresis Using β-Cyclodextrin as Chiral Selector

作　　者：周欣[1] 顾峻岭[1] 傅若农[1] 戴荣继[1] 张黎[2] 金声[2] 

机构地区：[1]北京理工大学化工与材料学院,北京100081 [2]北京大学化学与分子工程学院,北京100871

出　　处：《分析化学》1996年第5期497-500,共4页Chinese Journal of Analytical Chemistry

基　　金：国家自然科学基金;青年科学基金

摘　　要：毛细管电泳是一种分离手性化合物极为有效的工具。本文用β-环糊精作为手性选择剂在CZE的模式下对取代四氢β-咔啉类手性化合物进行了成功的拆分。研究了实验参数，如β-环糊精的浓度、pH值、离子强度和电压时分离效果的影响，并提出了可能的手性识别机理。High performance capillary electrophoresis is a powerful tool for optical resolutionof chiral compounds. In this work substituted tetrahydro-β-carboline chiral compounds were successfuIly resolved using β-CD as chiral selector in CZE mode. We studied the effects of experimental parameters (such as β-CD concentraion, pH value, concentration of buffer solution and applied voltage) on the separation. In addition, a possible mechanism of chiral recognition was discussed.

关 键 词：毛细管电泳 手性分离 环糊精 咔啉 手性化合物 

分 类 号：O658.9[理学—分析化学] O626.13[理学—化学]