无溶剂条件下代硫醇试剂与α,β-不饱和酮的迈克尔加成反应  

Thia-michael addition of thiol equivalents to α,β-unsaturated ketones under solvent-free conditions

作　　者：欧阳艳[1] 于海丰[1] 董德文[1] 刘群[1] 

机构地区：[1]东北师范大学化学学院

出　　处：《东北师大学报（自然科学版）》2006年第1期67-71,共5页Journal of Northeast Normal University(Natural Science Edition)

基　　金：国家自然科学基金资助项目(20272008)

摘　　要：用4,4-二烷硫基-3-烯-2-丁酮(1)作为无气味硫醇替代试剂在硫杂迈克尔加成反应中进行了研究.用浓盐酸做催化剂,将一系列α,β-不饱和酮(2)与1在无溶剂条件下混合发生反应,得到了相应的产率较高硫杂迈克尔加成产物(3),并对其反应机理进行了探讨.4,4 - Bis（alkylthio）but- 3 - en- 2 - one 1 have been investigated as odorless thiol equivalents in thia-michael addition reaction. Promoted by concentrated hydrochloric acid, a range of α,β- unsaturated ketones 2 reacted with 1 under solvent - free conditions affording the corresponding thia- michael adducts 3 in high yields. Moreover, a mechanism for this thia- michael addition reaction is proposed.

关 键 词：二硫缩烯酮 代硫醇试剂 硫杂迈克尔加成 Α Β-不饱和酮 无溶剂 

分 类 号：O621.3[理学—有机化学]