T细胞免疫球蛋白粘蛋白分子-3与免疫调节的研究进展  

Recent Studies on the Role of Tim-3 in Immunoregulation

作　　者：王毓琴[1] 杨培增[2] 吴长有（审校者）[3] 

机构地区：[1]中山大学中山眼科中心眼科学教育部重点实验室,广州510060 [2]眼科学教育部重点实验室（博士研究生 ） [3]中山大学基础医学院免疫学教研室

出　　处：《国际免疫学杂志》2006年第2期107-111,共5页International Journal of Immunology

基　　金：国家自然科学基金创新研究群体基金(30321004)

摘　　要：T细胞免疫球蛋白粘蛋白分子3(Tim3)是一种Ⅰ型膜表面蛋白分子,属于新近发现的T细胞免疫球蛋白粘蛋白分子家族的一员。Tim3分子只选择性表达在分化的Th1细胞而不是Th2细胞上,可以作为新的区分Th1和Th2细胞的表面标志。Tim3分子通过与CD4+CD25+调节性T细胞和或抗原提呈细胞上表达的Tim3配体相互作用,抑制Th1免疫应答,在自身和异体免疫性疾病以及免疫耐受中起着重要作用。T cell immunoglobulin-and mucin-domain-containing molecule-3 （Tim-3）, one of the recently identified Tim-gene family members, is a type-Ⅰ transmembrane protein preferentially expressed on differentiated Thl cells but not on Th2 cells. Tim-3 is, therefore, regarded as a novel cell-surface marker for the differentiation status of Th cells. The role of Tim-3 in T-cell differentiation and/or effector function has been studied in the past several years. Tim-3 acts as a negative regulator of Thl responses by a cognate interaction with its potential ligand on CD4^＋ CD25^＋ regulatory T cells and/or antigen presenting cells. Tim-3 pathway has been shoval to inhibit Thl mediated auto- and allo-immune responses and to facilitate the development of immunological tolerance.

关 键 词：T细胞免疫球蛋白粘蛋白分子-3 免疫)Th1细胞 T细胞免疫球蛋白粘蛋白分子-3配体 

分 类 号：R392[医药卫生—免疫学]