双氯芬酸锌的结构鉴定  

Structural Identification of Diclofenac Zinc

作　　者：张玉[1] 王凯平[2] 袁东锋[2] 戴立泉[2] 

机构地区：[1]华中科技大学同济医学院附属协和医院药剂科,武汉430022 [2]华中科技大学同济医学院药学院

出　　处：《中国药师》2006年第3期223-224,共2页China Pharmacist

基　　金：湖北省科技厅攻关项目(2001 AA301 B02)

摘　　要：目的:鉴定新型非甾体抗炎药双氯芬酸锌的分子结构及分子式。方法:以红外光谱和核磁共振氢谱对双氯芬酸锌进行结构鉴定,并采用络舍滴定法测定其锌含量。结果:综合红外光谱和核磁共振氢谱结果,确定了双氯芬酸锌的分子结构及分子式;络合滴定法测得锌含量为9．83％。结论:双氯芬酸锌的分子式为C28H16N2O4Cl4Zn,从分子式得到的锌含量与络合滴定法测得的锌含量相同。Objective： To identify the molecular structure of Dielofenac zinc （Dic-Zn）. Method： The molecular structure of Dic- Zn was identified by IR and ^1H-NMR, and the content of zinc in Dic-Zn was determined by complexometry. Result： The molecular structure and molecular formula of Dic-Zn were obtained from the results of IR and 1H - NMR; the content of zinc in Dic-Zn was 9.83% according to the results of eomplexometry. Conclusion： The molecular formula of Dic-Zn is C28H16N2O4Cl4Zn, and the content of zinc in Dic-Zn calculated from its molecular formula is equal to that determined by complexometric titration.

关 键 词：双氯芬酸锌 结构鉴定 分子结构 

分 类 号：R971.1[医药卫生—药品]