第三代头孢菌素的用量与大肠埃希菌、肺炎克雷伯菌耐药相关性分析  

Correlation Between Amount of Consumption of Third - generation Cephalosporins and Drug Resistance of Escherichia coli and Klebsiella pneumoniae

作　　者：张丽华[1] 尚谦[1] 于庆萍[1] 

机构地区：[1]内蒙古医学院第三附属医院,内蒙包头014010

出　　处：《中国药师》2006年第3期260-262,共3页China Pharmacist

摘　　要：目的:探讨三代头孢菌素的用量与大肠埃希菌、肺炎克雷伯菌耐药率的相关性。方法:采用回顾性调查方法,对2001-2004年大肠埃希菌、肺炎克雷伯菌的耐药率、三代头孢菌素的用药频度(DDDs)分别进行统计,用直线回归对耐药率与DDDs进行相关性分析。结果:大肠埃希菌对三代头孢菌素的总体耐药率明显高于肺炎克雷伯菌,大肠埃希菌对头孢曲松、头孢哌酮的耐药率呈逐年增高趋势。耐药率和DDDs相关性分析显示,头孢曲松的用药频度与大肠埃希菌、肺炎克雷伯菌的耐药率呈正相关(r=0．78),头孢他啶的用药频度逐年上升。结论:大肠埃希菌、肺炎克雷伯菌的耐药率的上升趋势与三代头孢菌素用量增加有关。Objective： To analyse the correlation of the drug resistance between Escherichia coli, Klebsiella pneumoniae and amounts of consumption of third-generation cephalosporins. Method： The resistance of E. coli and K. pneumoniae, and the DDDs of third-qeneration-cephalosporins were analysed respectivily. The relationship between drug risistance rate and DDDs was used the method of linear regression. Result： The resistance rate of E. coli was higher than that of K. pneumoniae. From 2001 -2004, the resistance rate of E. coli to cefoperazone and ceftfiaxone increased year by year. The analysis revealed a positive correlation of DDDs between the resistance of E. eoli and Klebsiella pneumoniae and to eeftriaxone （ r = 0. 78 ）, the DDDs of ceftazidime increased year by year. Conclusion： The increase of the resistance rate of E. Coli and K. pneumoniae is correlation between the increase of the amounts of third-generation cephalospofins usage.

关 键 词：三代头孢菌素 大肠埃希菌 肺炎克雷伯菌 耐药性 

分 类 号：R978.11[医药卫生—药品]