血清瘦素水平与胃癌患者营养状态之间的关系  

The relationship between serum leptin concentration and malnutrition of gastric cancer patients

作　　者：张予蜀[1] 袁捷[1] 张振玉[1] 孔超美[1] 杜同信[2] 王自正[2] 

机构地区：[1]南京医科大学附属南京第一医院消化科,南京210006 [2]南京市医学放射免疫检测中心,南京210006

出　　处：《江西医药》2006年第1期13-15,共3页Jiangxi Medical Journal

摘　　要：目的研究血清瘦素水平与胃癌患者营养状态之间的关系。方法37例胃癌患者和11例正常对照组分别测定血清瘦素以及身高体重指数(BMI)、血白蛋白、三头肌皮褶厚度(TSF)、上臂中心肌肉周径(MAC),理想体重百分比(NW%)和总淋巴细胞计数(LYM)。胃癌患者分为营养不良(Ⅰ组)和非营养不良(Ⅱ组)两组。结果所有患者(48例)的血清瘦素浓度与BMI、NW%、TSF、MAC呈显著正相关(P<0.001),而与ALB、LYM无显著相关性;胃癌组血清瘦素浓度显著低于II组及对照组,其中胃癌患者男性与女性血清瘦素浓度无差异。结论胃癌营养不良患者的瘦素水平低于非营养不良者及正常者,临床上可作为营养不良的诊断指标之一。Objectives To find the relationship between serum leptin concentration and malnutrition of gastric cancer patients.Methods The serum leptin concentration,Body nass index（BMI）,NW%,Triceps skin-fold thickness（TSF）,Mid-arm circumference（MAC）,Albumin（ALB） and Lymphocyte count（LYM） of 37 gastric cancer patients and 11 normal control were detemlined. The gastric cancer patients were divided into malnutrition group（14 cases）and non-malnutritlon group（23 cases ）.Results The serum leptin concentration of all patients （48 cases） were positive correlation with BMI,NW%,TSF and MAC （P〈0.001）,not with ALB and LYM;Serum leptin concentration in malnutrition group were significantly lower than non-malnutrltion group and control group, there were no difference between male and female. Conclution The serum leptin levels in gastric cancer malnutrition was lower than non-malnutrition and normal group,which can be one of the diagnostic criteria for malnutrition.

关 键 词：血清瘦素水平 胃癌患者 营养状态 血清瘦素浓度 三头肌皮褶厚度 总淋巴细胞计数 营养不良 身高体重指数 正常对照 血白蛋白 

分 类 号：R512.6[医药卫生—内科学] R735.2[医药卫生—临床医学]