健康成年人及患者外周血激活素A和卵泡休止素水平分析  

Analysis of activin A and follistatin levels in serum from normal and diseased subjects

作　　者：张鹏宇[1] 王奭骥[1] 张红军[1] 王世瑶[1] 柳忠辉[1] 

机构地区：[1]吉林大学基础医学院免疫学教研室吉林省神经免疫与临床免疫重点实验室,长春130021

出　　处：《中国实验诊断学》2006年第3期234-237,共4页Chinese Journal of Laboratory Diagnosis

基　　金：吉林省科技厅课题(980580);吉林省杰出青年基金项目(4-20-5)

摘　　要：目的探讨健康成年人外周血激活素A与卵泡休止素的关系及其在疾病状态下的变化。方法采用放射免疫测定(RIA)检测健康成年人及患者外周血激活素A水平,酶联免疫吸附试验(ELISA)检测健康成年人及患者外周血卵泡休止素水平。结果健康成年人外周血激活素A水平变化与年龄成正相关,随年龄的增加,激活素A水平增高;卵泡休止素与激活素变化相似,也随年龄增加而升高;外周血卵泡休止素水平与激活素水平变化正相关,r=0.86。卵巢癌、肾功能不全患者血中激活素A水平明显升高,P<0.01与P<0.05,糖尿病及甲状腺功能亢进患者未见明显变化;卵巢癌、肾功能不全患者血中卵泡休止素水平也明显升高,P<0.01。结论人外周血激活素A与卵泡休止素水平变化成正相关,卵泡休止素与激活素A水平升高与机体年龄及疾病状态有关。Objective To investigate the relationship between activin A and follistatin in serum from normal adults and the change of activin A and follistatin in diseased conditions. Methods Activin A levels in serum were detected by RIA and follistatin levels in serum were detected by ELISA.Results The change of activin A levels in serum from normal adults has a positive correlation with age, activin A increased with age ; follistatin varied as activin A and also increased with age ; the change of follistatin and activin A levels in serum from normal adults have a positive correlation,the correlation coefficient is 0.86.Activin A levels in serum from patients suffered from ovary cancer and renal failure increased significantly, P 〈 0.01 and P 〈 0.05,activin A from patients suffered from diabetes or hyperthyroidism had no obvious change; follistatin levels in serum from patients suffered from ovary cancer or renal failure also increased distinctly, P 〈 0.01 .Conclusion The change of follistatin and activin A levels in human serum have a positive cerrelation, both of the increase of activin A and follistatin have relationship with age and the state of disease.

关 键 词：激活素A 卵泡休止素 放射免疫测定 酶联免疫测定 

分 类 号：R817.4[医药卫生—影像医学与核医学] R446.6[医药卫生—放射医学]