IL-6对照射小鼠脾淋巴细胞亚群活性的影响  

The effects of IL-6 on the natural killing activity of spleen lymphocyte subsets in irradiated mice

作　　者：王红兵[1] 王绪[2] 刘永彪[2] 郝兴芝[2] 

机构地区：[1]徐州医学院附属医院肿瘤科,江苏徐州221002 [2]徐州医学院肿瘤研究所,江苏徐州221006

出　　处：《徐州医学院学报》2006年第2期103-105,共3页Acta Academiae Medicinae Xuzhou

基　　金：江苏省教育厅自然科学研究基金资助项目(98KJD320014)

摘　　要：目的研究白细胞介素6(IL-6)对照射小鼠脾淋巴细胞亚群自然杀伤活性的影响。方法BALB/C小鼠分为照射组、对照组和照射+IL-6组,采用Panning法从小鼠脾淋巴细胞中分离L3T4、Lyt2和B细胞,用3H-TdR释放实验检测脾淋巴细胞亚群自然杀伤活性。结果照射+IL-6组与对照组比较,3H-TdR释放量有显著性差异(P<0.01)。结论IL-6具有促进照射小鼠脾淋巴细胞亚群活性作用。Objective To study the effects of IL - 6 on the natural killing activity of spleen lymphocyte subsets in irradiated mice, Methods The spleen lymphocytes in irradiated mice were separated into L3T4, Lyt2 and B cells by a panning method. The natural killing activity of spleen lymphocytes was determined by means of 14 - TdR release assay. Results Significant differences in 14 - TdR release were found between the IL - 6 group and the control group （ P 〈 0.01）. Conchtsion IL- 6 is able to stimulate the killing activity of spleen lymphocyte subsets in irradiated mice.

关 键 词：小鼠 分次照射 淋巴细胞 白细胞介索6 自然杀伤活性 K562 S180 

分 类 号：R818.05[医药卫生—放射医学]