Structure-function Relationships in Human Hypoxanthine-guanine Phosphoribosyltransferase(HGPRT) by Random Mutagenesis  

作　　者：Luke Guddat Anthony Farlow John de Jersey 

机构地区：[1]Department of Biochemistry and Molecular Biology, University of Queensland, St Lucia, Queensland 4072, Australia

出　　处：《Chemical Research in Chinese Universities》2006年第2期251-252,共2页高等学校化学研究（英文版）

摘　　要：Hypoxanthine-guanine phosphoribosyltransferase （ HGPRT, EC 2.4.2.8） is a key enzyme of the purine salvage pathway, which allows recycling of purine bases into DNA and RNA. It is widely distributed in nature and has been studied both in prokaryotes and eukaryotes. In humans, a complete lack of HGPRT activity causes the Lesch-Nyhan syndrome, which is characterized by hyperuricaemia and neural disorders,Hypoxanthine-guanine phosphoribosyltransferase （ HGPRT, EC 2.4.2.8） is a key enzyme of the purine salvage pathway, which allows recycling of purine bases into DNA and RNA. It is widely distributed in nature and has been studied both in prokaryotes and eukaryotes. In humans, a complete lack of HGPRT activity causes the Lesch-Nyhan syndrome, which is characterized by hyperuricaemia and neural disorders,

关 键 词：Hypoxanthine-guanine phosphoribosyltransferase Random mutagenesis Structure-function relationship 

分 类 号：Q55[生物学—生物化学]