肺靶向甲强龙琥珀酸钠明胶微球的制备  

Preperation of Lung Targeting Gelatin Microspheres of Methylprednisolone Sodium Succinate

作　　者：汪自然[1] 徐启勇[1] 叶燕青[1] 陶兆武[1] 彭平[1] 

机构地区：[1]武汉大学中南医院呼吸内科,武汉430071

出　　处：《武汉大学学报（医学版）》2006年第2期196-199,共4页Medical Journal of Wuhan University

基　　金：湖北省科技攻关计划(编号:2004AA301C24)

摘　　要：目的:探讨肺靶向甲强龙琥珀酸钠明胶微球的制备、稳定性及体外释药特性。方法:采用二步法制备肺靶向甲强龙琥珀酸钠明胶微球,并结合甲强龙琥珀酸钠的水解特性测定其载药量和体外释药特性。结果:制备出吸胀后平均算术粒径(9.9±3.5)μm的微球,515μm的微球占82.7%,载药量20.5%,在pH7.4PBS缓冲液中的释药规律符合Weibull方程,t1/2为43.5min。微球在室温下放置3个月形态及载药量无明显改变。结论:本方法制备的甲强龙琥珀酸钠明胶微球可用于肺靶向治疗。Objective： To study the preparation techniques, stability and the release profile in vitro of gelatin microspheres （GMS） encapsulated with methylprednisolone sodium succinate （MPS）. Methods. Gelatin microspheres of methylprednisolone sodium succinate （MPS-GMS）were prepared by the two-step method, their drug contents which were corrected by the hydrolytic profile of MPS, and their release profile in vitro was studied. Results： The arithmetic mean diameter of MPS-GMS was 9.9±3.5 μm after swelling. There were 82.7% of the microspheres ranging from 5 to 15 μm. The drug content was 20.5%. The release profile in vitro （pH7.4 phoshate buffer） can be described by the Weibull equation. The t1/2 value was 43.5 min. The shape and drug content were stable for three months when stored at room temperature. Conclusion： MPS-GMS can be used for treatment of lung target.

关 键 词：甲强龙琥珀酸钠 明胶微球 肺靶向给药系统 

分 类 号：R944.9[医药卫生—药剂学]