威海地区抗淋球菌药物敏感性研究  

The antimicrobial susceptibility of Neisseria gonorrhoeae in Weihai

作　　者：刘卫兵[1] 王乖娟[1] 荆鲁华[1] 史同新[2] 

机构地区：[1]解放军第404医院皮肤科,山东威海264200 [2]青岛大学附属医院皮肤科

出　　处：《中国麻风皮肤病杂志》2006年第3期204-206,共3页China Journal of Leprosy and Skin Diseases

摘　　要：目的:研究威海地区淋病奈瑟菌(简称淋球菌)对抗菌药物的敏感性。方法:用淋球菌快速定量检测法,检测82株淋球菌对15种抗菌药物的体外药物敏感度,同时应用纸片扩散法(Kirby-Bauer法)进行对照。结果:82株淋球菌中检出11株PPNG菌株(13.41%)。耐青霉素的淋球菌耐药性已达62.2%。用纸片法测得四环素、青霉素和红霉素的耐药率分别为58.5%、52.4%和92.1%。1.2%的菌株耐大观霉素(MIC≥64μg/mL),但所有菌株均对头孢曲松敏感。对环丙沙星的耐药率为74.4%(MIC≥1μg/mL),对头孢噻甲羧肟及头孢呋肟的耐药率均为11.0%(MIC≥32μg/mL)。结论:头孢曲松及大观霉素对淋球菌抗菌活性最强,可作为首选药。Objective： To monitor the antimicrobial resistance of Neisseria gonorrhoeae from 2000 to 2003 in Weibai. Methods： Eighty- two strams of clinical Neisseria gonorrhoeae were collected in Weibai area and the rapid quantitative method of MIC was used for testing of 15 antimicrobial agents, controlled by Kirby - Bauer methed. Re. trolls： The antimicrobial resistance rate of Neisseria gonorrhoeae to penicillin was 62.2% and the positivity rate of PPNG was 13.14% （ 11 stains）. There was no difference between rapid quantitative method and paper diffusion method. The antimicrobial resistance rate to tetracycline （TE）, penicillin （PG） and erythromycin （E） were 58.5%, 52.4 and 92.1%, respectively. Only 1.2% strains resisted to spectinomycin （MIC≥64 μg/mL）. All strains were sensitive to ceftriaxone. The antimicrobial resistance rate to ciprofloxacin were 74.4% （MIC≥ 1 μg/ mL）. Conclusion： Spectinomycin- resistant Neisseria gonorrhoeae strain is rare. Ceftriaxone and spectinomycin are considered as effective drugs for the treatment of gonorrhea.

关 键 词：威海 淋球菌 耐药性 

分 类 号：R446.5[医药卫生—诊断学]