G蛋白β_3亚单位基因C825T多态性影响缬沙坦的降压疗效  

Effects of C825T polymorphism of G protein β_3 subunit gene on antihypertensive efficacy of valsartan

作　　者：华琦[1] 李东宝[1] 皮林[1] 许骥[1] 

机构地区：[1]首都医科大学宣武医院心内科,北京100053

出　　处：《中华老年心脑血管病杂志》2005年第5期314-316,共3页Chinese Journal of Geriatric Heart,Brain and Vessel Diseases

基　　金：首都医学发展基金(2002-2007)

摘　　要：目的探讨G蛋白β3亚单位基因C825T多态性与缬沙坦的降压疗效的关系。方法采用聚合酶链反应限制片段长度多态性方法检测147例健康人(对照组)和321例高血压病患者(高血压组)的G蛋白β3亚单位C825T多态性,其中102例高血压病患者口服缬沙坦4周。结果高血压组G蛋白β3亚单位C825T多态性中基因型频率(CC28.7%、CT 52.0%、TT 19.3%)、等位基因频率(C 54.7%、T 45.3%)与对照组基因型频率(CC 27.2%、CT 46.9%、TT25.9%)、等位基因频率(C 50.7%、T 49.3%)比较无显著性差异;缬沙坦对CT[(18.29±11.17)mm Hg,1 mm Hg=0.133 kPa]、TT[(25.63±22.68)mm Hg]、CT+TT[(19.25±13.20)mm Hg]基因型患者降低收缩压的作用强于CC基因型[(11.33±9.15)mm Hg,P<0.05];对CT[(15.03±9.35)mm Hg]、CT+TT[(14.50±9.23)mm Hg]基因型患者降低舒张压的作用强于CC基因型[(8.81±5.60)mm Hg,P<0.05]。结论G蛋白β3亚单位基因C825T多态性与缬沙坦的降压疗效相关,而与原发性高血压无关。Objective To investigate the relationship between G protein β3 subunit gene polymorphism and the response to antihypertensive treatment with valsartan. Methods Polymerase chain reaction combined with restriction enzyme digestion was used to detect the polymorphism of G protein β3 subunit gene （GNB3 gene） in 147 normotensive controls and 321 hypertensive patients. 102 hypertensive patients were treated with valsartan for 4 weeks. Results There was no significant difference in the GNB3 gene C825T polymorphism genotypes and alleles between hypertensive patients （ CC 28.7 %, CT 52.0 %, TT 19.3 %, C 50.7 %, T 49.3 % ） and normotensive controls（CC 27.2 %, CT 46.9 %, TT 25.9 %, C 50.7 %, T 49.3 % ）. Mean decreases in systolic blood pressure were significantly greater in CT, TT, CT ＋ TT genotypes [ CT（ 18.29 ± 11.17） mm Hg, TT （25.63 ± 22.68） mm Hg,CT ＋ TF（19.25 ± 13.20） mm Hg] than in CC genotype [（ 11.33 ± 9.15） mm Hg, P 〈 0.05 ]. Mean decreases in diastolic blood pressure were significantly greater in CT [ （ 15.03 ± 9.35） mm Hg] and CT＋TT[（14.50　± 9.23） mm Hg] genotypes than in CC genotype[（8.81 ±5.60 ）mm Hg, P 〈 0.05 ]. Conclusion The C825T polymorphism of G protein β3 subunit is related to the response to valsartan but not to essential hypertension.

关 键 词：GTP结合蛋白质类 抗高血压药 聚合酶链反应 基因频率 

分 类 号：R96[医药卫生—药理学]