血清总胆汁酸测定在诊断新生儿黄疸中的临床价值  

Clinic Application of Serum Total Bile Acid Determination in Diagnosis of Neonate Jaundice

作　　者：李朝晖[1] 曹友德[1] 李浩[1] 

机构地区：[1]湖南省人民医院检验科,湖南长沙410005

出　　处：《医学临床研究》2006年第2期209-210,共2页Journal of Clinical Research

摘　　要：【目的】探讨血清总胆汁酸(TBA)在新生儿黄疸诊断和治疗中的作用。【方法】采用循环酶速率法测定157例黄疸患儿(其中65例生理性黄疸,92例病理性黄疸)及103例正常新生儿血清TBA对照,同时对其肝功能相关项目进行测定,并进行比较分析。【结果】正常对照组血清TBA为(9.48±5.18)μmol/L;生理性黄疸患儿血清TBA为(8.96±6.42)μmol/L,与对照组比较无差异(P>0.05);病理性黄疸患儿血清TBA为(32.51±22.48)μmol/L,与对照组及生理性黄疸组比较差异具有显著性(P<0.01)。病理性黄疸组TBA与直接胆红素(DBIL)、丙氨酸氨基转移酶(ALT)、门冬氨酸氨基转移酶(AST)、碱性磷酸酶(ALP)、γ-谷氨酰转移酶(GGT)等肝功能指标显著正相关。【结论】血清TBA测定在新生儿黄疸的诊断中具有较好的特异性和灵敏性,可为临床提供诊断和治疗的依据。[Objective]To evaluate the value of serum total bile acid （TBA）in the diagnosis and treatment of neonate jaundice. [Methods]The serum TBA and liver function of 157 jaundice patients （including 65 physiologic jaundice and 92 pathologic jaundice patients） were detected and compared with 103 controls. TBA was detected by the circulation enzyme rate method. [Resuhs]The TBA value was （9.48± 5.18） μmol/L in controis, and （8.96±6.42） μmol/L in physiologic jaundice patients, showing no difference（ P 〉0.05）. While the TBA value in pathologic jaundice patients was （32. 51± 22. 48） /μmol/L, showing significant difference compared with the controls and the physiologic jaundice patients（ P 〈0.01）. The TBA value in pathologic jaundice patients showed positively correlated with DBIL, ALT, AST, ALP and GGT. [Conclusion]The serum TBA detecting in diagnosis of neonate jaundice shows preferable specificity and susceptivity, which can be used as basis for clinical diagnosis and treatment.

关 键 词：黄疸 新生儿/诊断 胆汁酸类和盐类/血液 

分 类 号：R722.17[医药卫生—儿科]