干扰素联合胸腺肽治疗慢性乙型肝炎的临床观察  

A Clinical Observation on Interferon-α Combined with Thymosin in the Therapy of Chronic Hepatitis B

作　　者：陈美鸿[1] 林庆东[1] 周君霞[1] 

机构地区：[1]中南大学湘雅医学院附属海口医院,海南海口570208

出　　处：《医学临床研究》2006年第2期223-225,共3页Journal of Clinical Research

摘　　要：[目的]观察α-干扰素联合胸腺肽治疗慢性乙型肝炎（CHB）的疗效.[方法] 180例患者随机分为α-干扰素联合胸腺肽、α-干扰素及胸腺肽三组,观察各组的ALT、HBV DNA、HBeAg、抗Hbe及肝纤维化指标,包括Ⅲ型前胶原肽（PCⅢ）、Ⅳ型胶原（ⅣC）、层粘蛋白（LN）、透明质酸（HA）的变化.[结果] 治疗结束时联合组的HBV DNA滴度的变化及转阴率、HBeAg阴转率、抗Hbe阳转率及肝纤维化指标的改善均明显高于另两组（P〈0.05～P〈0.01）,干扰素组优于胸腺肽组（P〈0.05）.随访6个月联合组的HBV DNA、HBeAg、抗Hbe等指标仍优于另两组（P〈0.05～P〈0.01）.[结论] α-干扰素联合胸腺肽是治疗CHB的有效组合.[Objective]To study the clinical efficacy of Interferon-α combined with thymosin in the therapy of CHB. [Methods]One hundred and eighty cases of CHB were randomly divided into IFN-α with thymosin, IFN-α and thymosin groups to observe ALT, HBVDNA, viral markers and serum hepatic fibrosis indexes including PCⅢ,Ⅳ C, LN, HA changes. [Results]At the end of the treatment, the drop of HBV DNA level ,the negative rate of HBV DNA and HBeAg, the positive rate of HBeAb were higher in united group than in other two groups（ P 〈0. 05～P 〈0. 001）while the serum levels of PCⅢ ,ⅣC, LN, HA, were much lower in united group than other two groups（ P 〈0. 01） ,The IFN-α group was more effective than thymosin group（ P〈0. 05）. After 6 months follow-up, united group still showed better results than the others regarding HBV DNA, HBeAg, HBeAb（ P 〈0. 05～ P 〈0. 001）. [Conclusions] IFN-α combined with thymosin is effective in the therapy of CHB.

关 键 词：肝炎 乙型 慢性/药物疗法 干扰素类/治疗应用 胸腺素/治疗应用 

分 类 号：R513.62[医药卫生—内科学]