尿纤维连接蛋白检测在老年人早期糖尿病肾病中的诊断价值  

The Clinical Signification of Urine Fibronectin Measurement in Early Diabetic Nepropathy in Elderly

作　　者：姚坚坚[1] 钱芸娟[1] 林琦[1] 

机构地区：[1]广东省老年医学研究所肾内科,广州510080

出　　处：《中国中西医结合肾病杂志》2006年第3期146-148,共3页Chinese Journal of Integrated Traditional and Western Nephrology

基　　金：广东省医学科学技术研究基金资助项目(No.A2001043)

摘　　要：目的:探讨检测老年2型糖尿病(DM)患者尿纤维连接蛋白(FN)对老年人糖尿病肾病(DN)早期诊断的临床价值。方法:检测53例老年2型糖尿病患者及27名正常老年人的尿FN、尿微量白蛋白(M-Alb)、β2-微球蛋白(β2-MG)、空腹血糖及糖化血红蛋白,并进行分析比较。结果:正常白蛋白尿DM组的尿FN(9.80±4.71)μg/mmol.cr及微量白蛋白尿DM组的尿FN(30.93±19.28)μg/mmol.cr明显高于正常老年对照组的尿FN(3.91±3.68)μg/mmol.cr(t′分别为5.89、6.75,P均<0.01),且微量白蛋白尿DM组尿FN水平较正常白蛋白尿DM组明显增高,两组间有统计学差异(t′=5.14,P<0.01)。相关分析显示尿FN与尿M-Alb、β2-MG的排泄量、糖化血红蛋白均呈显著正相关(r分别为0.5059、0.4570、0.6624,P均<0.01)。结论:尿FN检测似可作为老年2型DN早期诊断的一项敏感指标。Objective.To investigate the diagnostic clinical signification of urine fibronectin （FN）measurement in old patients with early diabetic nephropathy. Methods. Urinary FN, mieroalbumin and microglobulin β2, blood glucose and glycohemoglobuin were examined in 53 eases of old diabetics type Ⅱ and 27 cases of normal control. Results： Urine FN in DM groups who have urine microalbumin （30.93 ± 19.28）μg/mmol. cr was higher than that in DM patients whose urine albutmin was normal （ 9. 80± 4.71 ）μ/mmol. cr. Both were significantly higher than the normal control group（3.91 ± 3, 68）μ/mmol, cr（P 〈 0.01 ）, Furthermore, the differences in FN between both DM groups were also significant （P 〈 0.01 ） Correlation analysis showed urine FN was significantly correlated with urine microalbumin, microglobulin β2 and glycohemoglobuin （ r was 0. 5059,0. 4570,0. 6624, all P 〈 0.01 ）. Conclusion： Detection of urinary FN may be used as an sensltive index in detecting DN in old patients.

关 键 词：糖尿病肾病 纤维连接蛋白 尿微量白蛋白 糖化血红蛋白 

分 类 号：R692[医药卫生—泌尿科学]