血浆置换联合拉米夫定对重型肝炎HBV动力学影响  

Effect of plasma exchange combined with lamivudine on dynamics of serum HBV in patients with hepatitis gravis

作　　者：鲍旭丽[1] 段钟平[1] 单晶[1] 韩大康[1] 赵军[1] 

机构地区：[1]首都医科大学附属北京佑安医院人工肝中心,北京100069

出　　处：《中国血液净化》2006年第1期41-43,共3页Chinese Journal of Blood Purification

基　　金：北京市科技计划重大项目(H020920020091)资助

摘　　要：目的观察血浆置换(PE)联合拉米夫定(LAM)治疗慢性重型乙型肝炎对HBV造成的影响。方法选择首都医科大学附属北京佑安医院人工肝中心11例慢性重型乙型肝炎患者随机分为血浆置换与拉米夫定联合、单纯拉米夫定2组,治疗12周,观察治疗前、治疗后一系列病毒载量的变化。结果第1组的抑制病毒生成效率范围为38.2%～74.6%,平均55.0%,第2组的抑制病毒产生效率范围为67.6%～89.7%,平均75.1%。对2组效率进行t检验,差异有显著性。结论提示PE联用LAM可以在PE后较低病毒血症水平的基础上发挥LAM对病毒的抑制作用,巩固PE对病毒的清除作用,抑制病毒复制的效率较高。Objective To observe the influence to HBV in peripheral blood of Lamivudine combined with plasma exchange. Methods Eleven cases with chronic severe hepatitis B were enrolled and receiced Lamivudine or Lamivudine combined with plasma exchange treatment for 12 weeks. Results There was significant difference of mean antivira] efficacy between the two groups. Conclusion Combinaed therapy of PE and LAM has higher efficacy than LAM alone for inhibiting HBV replication.

关 键 词：血浆置换 重型肝炎 HBV动力学 

分 类 号：R318.14[医药卫生—生物医学工程]