乌拉地尔对吗啡导致的大鼠空间记忆障碍的改善作用  

Effect of Urapidil on Morphine-induced Impairment of Spatial Memory in Rats

作　　者：李新旺[1] 张滨[1] 于萍[1] 徐爱红[2] 

机构地区：[1]首都师范大学心理系,北京100089 [2]首都师范大学生物系,北京100089

出　　处：《中国心理卫生杂志》2006年第3期141-143,共3页Chinese Mental Health Journal

基　　金：国家攀登计划项目(95-专-09);高等学校博士学科点专项基金项目(20040028001);北京市重点实验室(学习与认知);北京市重点专业(发展与教育心理学)资助。

摘　　要：目的研究吗啡对大鼠空间记忆的影响和5-HT1A受体激动剂乌拉地尔对这种影响的改善作用。方法;训练大鼠学习Morris水迷宫任务,检验它们在注射药物情况下回忆空间任务的能力。结果同时注射乌拉地尔(20mg/kg)和吗啡(10mg/kg)的大鼠通过回忆寻找Morris水迷宫隐蔽站台的潜伏期(第一次测验,30.43±9.46;第二次测验,41.00±10.30;单位,秒),显著短于单独注射吗啡的动物(第一次测验,87.00±22.53;第二次测验,96.67±20.85;均为P<0.01);而与对照组动物(第一次测验,16.17±3.74;第二次测验,16.33±2.36)没有显著差别。单因素方差分析对照组和给药情况下吗啡组、吗啡-纳洛酮组和吗啡-乌拉地尔组回忆测验结果分别为第一次测验,16.17±3.74、87.00±22.53、34.67±6.75、30.43±9.46,F1(3,21)=5.866,P<0.01;第二次测验,16.33±2.36、96.67±20.85、22.17±6.46、41.00±10.30,F2(3,21)=8.94,P<0.01。结论乌拉地尔能够显著改善吗啡导致的大鼠空间记忆障碍。Objective： To investigate effect of morphine on spatial memory and effect of urapidil on morphineinduced spatial memory impairment in rats. Methods： Rats were trained to learn Morris water maze task and their ability to recall spatial task was examined after receiving injections of drugs. Results： For finding the covert platform by recall in Morris water maze, the latencies of rats with injections of morphine （10mg/kg） and urapidil （20mg/kg; test 1,30. 43±9. 461 test 2, 41.00±10. 30 ; unit, second） were significantly shorter than that of the rats with injections ofmorphine （ 10mg/kg; test 1, 87.00±22. 53 ; test 2, 96. 67±20. 85 ） （ P 〈 0. 01 ）, but there was no difference between the latencies of rats with injections of morphine and urapidil and that of rats with injection of saline （ test 1,16. 17±3.74 ; test 2, 16. 33±2. 36 ; P 〉 0. 05 ） . One way ANOVA showed that, in the first treatment, the latencyof control group, morphine group, morphine-naloxone group and morphine-urapidil group were 16. 17± 3. 74, 87. 00±22. 53, 34. 67 ±6. 75 and 30. 43 ±9. 46 respectively （ F1（ 3, 21 ）=5. 866, P 〈 0. 01 ） . In the second treatment,that of the four groups were 16. 33± 2. 36, 96.67±20. 85, 22. 17± 6. 46 and 41.00±10. 30 respectively （ F2 （ 3,21 ） = 8.94, P 〈 0. 01 ） . Conclusion： urapidil could appreciably attenuate morphine-induced impairment of spatialmemory

关 键 词：空间记忆 MORRIS水迷宫 动物实验 吗啡 5-HT1A受体激动剂 乌拉地尔 

分 类 号：B845.4[哲学宗教—心理学]