A multiscale model for analyzing the synergy of CS and WSS on the endothelium in straight arteries  

作　　者：Kairong Qin Zonglai Jiang Hui Sun Keqin Gong Zhaorong Liu 

机构地区：[1]Institute for Mechanobiology & Medical Engineering,Shanghai Jiaotong University,Shanghai 200030, China [2]Department of Mechanics & Engineering Science,Fudan University,Shanghai 200433, China

出　　处：《Acta Mechanica Sinica》2006年第1期76-83,共8页力学学报（英文版）

基　　金：The project supported by the National Natural Science Foundation of China (10132020 and 10472027);The English text was polished by Yunming Chen.

摘　　要：A multiscale model was proposed to calculate the circumferential stress （CS） and wall shear stress （WSS） and analyze the effects of global and local factors on the CS, WSS and their synergy on the arterial endothelium in large straight arteries. A parameter pair [Zs, SPA] （defined as the ratio of CS amplitude to WSS amplitude and the phase angle between CS and WSS for different harmonic components, respectively） was proposed to characterize the synergy of CS and WSS. The results demonstrated that the CS or WSS in the large straight arteries is determined by the global factors, i.e. the preloads and the afterloads, and the local factors, i.e. the local mechanical properties and the zero-stress states of arterial walls, whereas the Zs and SPA are primarily determined by the local factors and the afterloads. Because the arterial input impedance has been shown to reflect the physiological and pathological states of whole downstream arterial beds, the stress amplitude ratio Zs and the stress phase difference SPA might be appropriate indices to reflect the influences of the states of whole downstream arterial beds on the local blood flow-dependent phenomena such as angiogenesis, vascular remodeling and atherosgenesis.A multiscale model was proposed to calculate the circumferential stress （CS） and wall shear stress （WSS） and analyze the effects of global and local factors on the CS, WSS and their synergy on the arterial endothelium in large straight arteries. A parameter pair [Zs, SPA] （defined as the ratio of CS amplitude to WSS amplitude and the phase angle between CS and WSS for different harmonic components, respectively） was proposed to characterize the synergy of CS and WSS. The results demonstrated that the CS or WSS in the large straight arteries is determined by the global factors, i.e. the preloads and the afterloads, and the local factors, i.e. the local mechanical properties and the zero-stress states of arterial walls, whereas the Zs and SPA are primarily determined by the local factors and the afterloads. Because the arterial input impedance has been shown to reflect the physiological and pathological states of whole downstream arterial beds, the stress amplitude ratio Zs and the stress phase difference SPA might be appropriate indices to reflect the influences of the states of whole downstream arterial beds on the local blood flow-dependent phenomena such as angiogenesis, vascular remodeling and atherosgenesis.

关 键 词：Stress Synergy Endothelium Factor Multiscale model 

分 类 号：O343[理学—固体力学]