小学生接种乙型肝炎血源疫苗后七年效果观察  

Seven┐yearFolow┐upinPupilsImmunizedwithHepatitisBVacineandItsRevaccination

作　　者：李雪翔[1,2,3,4,5,6] 邬嘉生 刘建福[1,2,3,4,5,6] 徐建兴[1,2,3,4,5,6] 肖亮明[1,2,3,4,5,6] 谢广中[1,2,3,4,5,6] 刘德堂 王佐沂[1,2,3,4,5,6] 熊素英 杨心乐 张谋鸿 杜立效 赵世立 

机构地区：[1]卫生部上海生物制品研究所 [2]上海市卢湾区卫生防疫站 [3]山东省莒南县卫生防疫站 [4]上海市长宁区卫生防疫站 [5]山东省临沂地区卫生防疫站 [6]山东省卫生防疫站

出　　处：《中华预防医学杂志》1996年第3期151-153,共3页Chinese Journal of Preventive Medicine

摘　　要：为了解乙型肝炎血源疫苗的免疫持久性，对３４４例小学生追踪随访，并采集血标本，以ＡｂｂｏｔＲＩＡ法检测ＨＢｓＡｇ、抗－ＨＢｃ和抗－ＨＢｓ。第七年时，抗－ＨＢｓ≥１０ＩＵ／Ｌ者为５５．４％～７５．０％，ＧＭＴ为２０．９～６５．３ＩＵ／Ｌ；抗－ＨＢｓ滴度越高，下降至１０ＩＵ／Ｌ以下的时间越长；免疫后７年时，对６６例抗－ＨＢｓ不同滴度者给予第４针（１０μｇ）疫苗后１月，抗－ＨＢｓ升高６．３～５７．７倍。说明儿童接种乙型肝炎血源疫苗后７年内可不必加强接种。Inordertoevaluateimmunepersistenceofplasma-derivedhepatitisBvaccine(HBV),344childreninaprimaryschoolwerefolowedupforsevenyearsbydetectionofserumHBsAg,anti-HBcandanti-HBswithradioimmunoassay(RIA)usingAbbotreagentkits.Intheseventhyearafterthree-doseHBVimmunization,levelofanti-HBsin55.4%～75.0%ofthevaccineewasgreaterthan10IU/L,withageometricmeantiter(GMT)of20.9～65.3IU/L.Thehigherthelevelofanti-HBs,thelongerthedurationofitsdecreasefrommorethantolessthan10IU/L.Sevenyearsafterimmunization,66childrenwithvariedserumlevelsofanti-HBswerereceivedafourthdoseof10μgHBV,andonemonthafterrevacination,theirlevelsofanti-HBsincreasedby6.3～57.7times.ItsuggestsrevacinationofHBVisnotnecessaryforchildrenvaccinatedwithinsevenyears.

关 键 词：乙型肝炎 疫苗 免疫记忆 接种 

分 类 号：R512.620.1[医药卫生—内科学]