蛋白质水平对大鼠胚胎期脑发育的影响  

THE EFFBCT OF DIETARY PROTEIN LEVELS ON BRAIN DEVELOPMENT IN EMBRYONIC RAT

作　　者：施明[1] 萧锦腾[1] 李树田[1] 洪燕[1] 

机构地区：[1]军事医学科学院卫生学环境医学研究所

出　　处：《解放军预防医学杂志》1996年第1期24-28,共5页Journal of Preventive Medicine of Chinese People's Liberation Army

摘　　要：成年雌性Ｗｉｓｔａｒ大鼠３０只，体重２４０±２６．５ｇ，等分为Ⅰ、Ⅱ、Ⅲ３个组。各组蛋白质分别占饲料的４０％，２０％和８％。饲养４３天（受孕前２１天），观察饲料中蛋白质水平对胚胎期大鼠脑发育的影响。结果表明，新生幼鼠体重和脑重，Ⅰ组最重，分别为６．９５ｇ和２４０．９ｍｇ；Ⅱ组次之，分别为６．５７ｇ和２３７．８ｍｇ，Ⅲ组最轻，分别为５．６２ｇ和２１０．９ｍｇ。各组间体重均有显著差别（Ｐ＜０．０１），Ⅲ组脑重明显低于Ⅰ、Ⅱ组（Ｐ＜０．０１）。各组脑中蛋白质含量依次为１０．０３ｍｇ、９．０９ｍｇ和７．４６ｍｇ（Ｐ＜０．０１或＜０．０５），脑中ＤＮＡ和ＲＮＡ水平以及每ｇ脑组织中ＲＮＡ含量也是Ⅰ组最高，Ⅲ组明显低于其它两组。说明蛋白质水平不同对大鼠胚胎期脑生长发育有一定影响。he effcts of dietary protein levels on brain development in embryonic rat were observed.30 ad ult female Wistar rats were randomly alloca- ted inito 3 groups of 10 each byequal average inItial weight,i.e. group l(40% protein of ration by weight),group Ⅱ(20%protein of ration by weigh)and groiip Ⅲ(8%protc,in of ration by lireight).The experimentdl animals were pair一fed for l3 days(before gestation 2l days)。The resuIts showed that the bodyand brain weight of neonatal rats of group I were 6.95g and 240.9mg respectively, while that of group Il were 6.57g and 237.8mg and group IIl 5.62g and 210.9mg respectively.Body weights among these group were significantly different (P<0.01).The brain weight of group Ⅲ was signiifieanty lower as comparedwith groups Ⅰ and Ⅱ(P<0.01)The brain prc1tein contents of group Ⅰ and group Ⅱ were higher than those ofgroup Ⅲ(P<0.0i),The brain DNA,RNA contents and RNA content per g fresh were similar to body weight.These results indicate inadequate dietary protcin may liav e detrimental effect on brain developmcnt in em- brvonic rats.

关 键 词：蛋白质 胚胎期 脑发育 

分 类 号：R321.5[医药卫生—人体解剖和组织胚胎学] R715.3[医药卫生—基础医学]