血管内皮剥脱后大鼠血管平滑肌线粒体摄钙功能的变化  

CHANGES OF MITOCHONDRIAL CALCIUM UPTAKE OF VSMC AFTER BALLOON DENUDATION

作　　者：刘乃奎[1] 任晓燕[1] 岑链珍 唐朝枢[1] 苏静怡[1] 

机构地区：[1]北京医科大学心血管基础研究所,青岛医学院病理生理学教研室

出　　处：《北京医科大学学报》1996年第2期89-91,共3页Journal of Peking University(Health Sciences)

摘　　要：目的：探讨血管损伤与血管平滑肌线粒体钙转运的关系。方法：建立大鼠腹主动脉球囊内皮剥脱模型，用同位素标记。结果：内皮损伤可致ＶＳＭＣ增生、内膜增厚。线粒体摄钙功能在内皮剥脱后３－ｄ和１０ｄ时明显增强；线粒体摄钙初速率和最大摄钙量均显著高于对照。结论：内皮剥脱后ＶＳＭＣ增生过程中线粒体摄钙功能发生了相应变化。objective:Investigating the relationship hetween vascular injury and mitochondrial calcium transport of vsMC. Methodx:On aorta ballon deendothelization model of rats. using isotope labeled methods. Results:vascular endothelium injury induced VSMC proliferation. vascular intima thtcken-ing. Calcium uptake of mitochondria significantly increased 3 daysand10 daysafter denuation.the ini-tial rates and Vmax of mitochondrial calcium uptake were superior to control.Conclusion: the function of mitochondrial calcium uptake is changed during VSMC proliferation induced by hallon denudation.

关 键 词：血管内皮 线粒体 平滑肌 钙 代谢 血管狭窄 

分 类 号：R543.02[医药卫生—心血管疾病]