怒 恐伤气大鼠血浆ACTH CORT IL-2 IL-8变化的比较研究  

Compare of ACTH CORT IL-2 IL-8 in Serum in Rats with Qi Injured by Anger and Fear

作　　者：刘晓伟[1] 曲宏达[1] 张红梅[1] 解亚宁[1] 董秋安[1] 许丽[1] 许文学[1] 邓虹珠[1] 傅江南[1] 李晓明[1] 

机构地区：[1]南方医科大学中医系临床基础教研室,广东广州510515

出　　处：《辽宁中医杂志》2006年第2期239-240,共2页Liaoning Journal of Traditional Chinese Medicine

基　　金：国家自然科学基金资助项目(30271567);广东省中医药管理局基金资助项目(02102074)

摘　　要：目的:比较分析怒、恐伤气大鼠内分泌、免疫变化产生差异性的机理。方法:根据M egan E与Takash i方法制作怒、恐应激动物模型,采用放免方法,检测愤怒和恐惧应激后大鼠血浆促肾上腺皮质激素(ACTH)、血清皮质醇(CORT)、白细胞介素2(IL-2)和白细胞介素8(IL-8)的含量。将实验组与实验组、实验组与正常组进行对照。结果:恐惧组、愤怒组与正常对照组ACTH、CORT有显著性差异(P<0.05,P<0.01),IL-2有显著性差异(P<0.01);恐惧组ACTH与IL-2明显高于愤怒组(P<0.01):IL-8水平各组无显著性差异(P>0.05)。结论:愤怒、恐惧不同情志导致气机紊乱病机有别,对内分泌、免疫影响亦不同。Objective ： Compare and analyze the diversity of endocrine and immunity in rats with Qi injured by Anger and Fear. Methods ：Animal models were established according to Megan E and Takashi ＇s methods respectively. Serum adrenoeorticotropic hormone （ACTH）, cortisol （ CORT）, interleuking （IL） - 2, IL - 8 were analyzed through RIA. Compare anger group and fear group, model groups and normal group. Results ： Anger and fear could significantly increase the level of ACTH and CORT in plasma （ P 〈 0.05, P 〈 0.01 ） ,reduce IL -2（ P 〈0.01 ）. The level of ACTH and IL - 2 in fear group are higher than that of anger group significandy （ P 〈 0.01 ）. IL- 8 in each group have no significant discrepancy （ P 〉 0.05 ）. Conclusion ： Qi injured by anger and fear have different form and influence on endocrine - immunity.

关 键 词：愤怒 恐 内分泌 免疫 对照观察 

分 类 号：R2-03[医药卫生—中医学]