NIDDM病人空腹血糖遗传度分析  

Heritability Analysis of Fasting Glucose for NIDDM

作　　者：杨新军[1] 王建华[2] 王正伦[2] 武光林 

机构地区：[1]河北省承德医学院流行病学教研室,承德067000 [2]天津医科大学流行病学教研室,天津300070

出　　处：《遗传》1996年第4期23-25,共3页Hereditas（Beijing)

摘　　要：应用数量性状遗传度估计方法（相关回归法），对50户NIDDM病倒核心家庭成员空腹血糖的遗传度进行估计，以探讨遗传和环境因素对血糖这一数量性状的决定作用。结果表明，经年龄和环境因素校正血糖后，用子女对中亲回归估计的空腹血糖遗传度为0．35768±0．2024,说明遗传因素虽起一定作用，但环境因素的作用更不容忽视，即支持NIDDM为多因子遗传病。空腹血糖的遗传未显示母体效应。The heritability of fasting glucose was cstimated on thc members of 5O core families by using the mcthod of corrclation and regression of quantitative character heritability so as to research the role of gcnetic and environmental factors in NIDDM. The result showed that the heritabi1ity of glucose, adjusted by agc and environmental factors, of the offspring on mid-parent was 0.35768±0.2024. This suggestedthat in NIDDM genetic factors play a role to some cxtcnt, but the influence of environmental factors ismore signiflcant, i.e. NIDDM being considered as a multifactorial disease. The genetics of fasting glucosedid not show the maternal effects.

关 键 词：糖尿病 非胰岛素依赖型 血糖 遗传度 

分 类 号：R587.102[医药卫生—内分泌]