双歧杆菌对失血后肠源性感染的预防作用  

EFFECT OF BIEIDOBACTERIA ON ENTEROGENOUS INFECTION SECOND TO HEMORRHAGE

作　　者：石汉平[1] 秦路平[1] 缪明永[1] 杨林[1] 高瀚[1] 华积德[1] 徐仁宝[1] 

机构地区：[1]广州南方医院普外科,第二军医大学药学院生药教研室,第二军医大学生化教研室,上海长征医院普外科,上海长海医院普外科,第二军医大学病理生理教研室

出　　处：《中国微生态学杂志》1996年第4期1-4,共4页Chinese Journal of Microecology

摘　　要：本文观察双歧杆菌对失血后肠源性感染的预防作用，将大鼠分为假处理、失血、双歧杆菌＋失血，新霉素＋失血４组。后两组实验前分别灌注双歧杆菌或新霉素，假处理动物麻醉插管不放血，后３组动物放血２ｏ％，６ｈ后每组１０只动物活杀取样。发现：失血组大鼠１０ｈ存活率降低，血浆ＥＴ、ＩＬ—１升高，细菌培养阳性标本增多，小肠杆／球菌比值增大，与假处理组相比差异显著。双歧杆菌治疗组大鼠时间存活率增加，血浆ＥＴ、ＩＬ—１无明显升高，细菌培养阳性标本减少，杆／球菌比例正常，与失血组相比差异显著。新霉素治疗组上述各项指标与失血组相比无显著改善。提示双歧杆菌能有效地预防失血后肠源性感染。Effect of bifidobacteria on enterogenous infection second to hemorrhage was observed.Rats were divided into 4 groups:sham,hemorrhage, bifidobacteria plus hemorrhage,neomycin plus hemorrhage.Sham treated rats were not bled after anesthetized and catheterized,while the other were shed 20% of their total blood volume. Bifidobacteria or neomycin were administered to rats 3 days before experiment.Ten of 25 rats in each groups were sacrificed and samples were collected 6 hs after different treatment.It was found 10 hs survival rate decr eased, plasma ET and IL-1 rised, bacteria positive samples increased, and ratio of E.coli/enterococci enlarged in hemorrhaged rat,the difference were significant as compared with those of sham rat. Bifidobacteria remarkedly improved the above parameters,but no obvious improvement were observed in neomycin treated rats as compared with those in hemorrhage gruop.It is suggested that bifidobacteria could effectively prevent enterogenous infection second to hemorrhage.

关 键 词：感染 失血 肠源性感染 

分 类 号：R630.1[医药卫生—外科学]