聚腺苷二磷酸核糖基聚合酶──在DNA损伤修复及程序性死亡中的作用  

Poly (ADP-ribose) polymerase: Its Role in the Repairing of DNA Damages and Programmed Cell Death

作　　者：罗瑛[1] 孙志贤[1] 吴祖泽[1] 

机构地区：[1]北京放射医学研究所

出　　处：《生物化学与生物物理进展》1996年第4期308-312,共5页Progress In Biochemistry and Biophysics

基　　金：国家自然科学基金

摘　　要：聚腺苷二磷酸核糖基聚合酶（ｐｏｌｙ（ＡＤＰ－ｒｉｂｏｓｅ）ｐｏｌｙｅｒａｓｅ，ＰＡＲＰ）是存在于多数真核细胞中的一个蛋白质翻译后修饰酶，它可催化组蛋白Ｈ１等重要核蛋白及它自身的聚腺苷二磷酸核糖基化作用．细胞受到外界损伤因子作用时，ＤＮＡ发生链断裂，ＰＡＲＰ结合到ＤＮＡ断裂口，其催化活性被激活，修饰受体蛋白，进而引发一系列级联反应这种性质使ＰＡＲＰ有可能作为细胞内的分子感受器和传感器，启动细胞内对损伤作出反应的信号传导机制，从而根据细胞受损程度决定细胞的命运：修复或是死亡．Poly (ADP-ribose ) Polymerase (PARP) is a kind of enzyme which responsible for posttranslation modification of proteins. It exists in many eukaryotic cells and catalyzes poly ADP-ribosylation of nuclear proteins including histone HI and itself. When cells are damaged by toxic agents that induce DNA breakages, PARP molecules will bind to DNA breakage and their catalytic activity is activated. Then they modify their acceptor protein and trigger a set of cascade reactions. Thus PARP is a POssible molecular sensor and transducer to initiate the signal transferring path for reacting to damages of the cell.The information which they passed may decide the fate of a cell: repair or death.

关 键 词：聚腺苷二磷酸 核糖基聚合酶 DNA损伤 修复 

分 类 号：Q555.02[生物学—生物化学]