血清HCV RNA检测在预防输血后丙型肝炎中的意义  

Significance of blood HCV RNA screening in the prevension of post-transfusion hepatitis C

作　　者：张英[1] 李晶[2] 刘玉风 赵宏伟[1] 田庚善[3] 

机构地区：[1]黑龙江省医院感染内科,哈尔滨150036 [2]黑龙江省医院检验科,哈尔滨150036 [3]北京大学第一医院感染疾病科

出　　处：《中华实验和临床病毒学杂志》2006年第1期70-72,共3页Chinese Journal of Experimental and Clinical Virology

摘　　要：目的探讨血清HCVRNA检测在预防输血后丙型肝炎中的意义。方法用ELISA法检测2000年1月至2003年12月末抗-HCV阴性的全血标本56400份次,再进行RT-PCR(荧光适时技术)检测HCVRNA,并对输过HCV RNA筛查阴性血液的患者进行追查。结果HCV RNA阳性率为2·5‰(146/56400)。对输过HCVRNA筛查阴性血液的患者追查结果,无一例发生输血后丙型肝炎。结论对抗-HCV阴性的血液标本用敏感的试剂进行HCVRNA检测在预防输血后丙型肝炎中不但有效,而且可行。Objective To investigate the significance of blood HCV RNA screening in the prevention of post-transfusion hepatitis C. Methods Totally 56 400 anti-HCV negative blood samples collected from Jan. 2000 to Dec. 2003 were tested for HCV RNA by RT-PCR, and the patients who received the HCV RNA negative blood were followed up. Results The HCV RNA positive rate was 2.5%0 （ 146/56 000） and none of the patiens followed up suffered from HCV infection. Conclusion HCV RNA screening for the anti-HCV negative blood samples is very effective and feasible for prevention of post-transfuslon hepatitis C.

关 键 词：肝炎病毒 RNA 输血传播病毒 肝炎 丙型 

分 类 号：R450[医药卫生—治疗学]