养肝利胆颗粒抗炎镇痛解痉作用实验研究  

Experimental Study on the Anti-inflammation,Analgesia and Spasmolysis by YangGanLiDan Granule

作　　者：高建平[1] 金若敏[1] 朱培庭[2] 吴耀平[1] 成秉辰[1] 沈伟[1] 陈艳艳[1] 

机构地区：[1]上海中医药大学,上海201203 [2]上海中医药大学附属龙华医院,上海200032

出　　处：《中国实验方剂学杂志》2006年第3期59-61,共3页Chinese Journal of Experimental Traditional Medical Formulae

摘　　要：目的:观察与养肝利胆颗粒功能主治相关的抗炎、镇痛和解痉作用。方法:给动物灌服药物,采用小鼠耳肿胀法、大鼠足肿胀法、小鼠扭体法、热板法和离体豚鼠胆囊试验观察药物的作用。结果:养肝利胆颗粒能明显抑制小鼠耳肿胀度和大鼠足跖肿胀,可对抗醋酸致小鼠扭体反应,提高小鼠对热的痛阈值,可缓解乙酰胆碱致离体胆囊痉挛作用。结论:养肝利胆颗粒具有抗炎、镇痛和解痉等作用。Objective： To investigate the functions of YangGanLiDan Granule （YGLDG） on anti-inflammation, pain relief and spasmolysis. Methods： The models of mouse ear tumefaction caused by xylene and rat foot tumefaction caused by carragecnan were used to observe the anti-inflammatory action of YGLDG via oral adiminstration. The effect of YGLDG on relieving pain was tested by counting body twisting induced by glacial acetic acid and measuring the latent period of licking hind foot with the hot plate method in mice. The effect on spasmolysis was studied by using isolated gallbladder of guinea pig. Results： The drug could restrain mouse ear tumcfaction and rat foot tumefaction, reduce mouse body twisting numter in glacial acetic acid model and elevate the pain threshold with hot plate method, relax the spasticity of isolated gallbladder of guinea pig caused by Ach. Conclusion： The results show that YGLDG has the effects on anti-inflammation, pain relief and relaxtion of spasticity.

关 键 词：养肝利胆颗粒 抗炎 镇痛 解痉 

分 类 号：R285.5[医药卫生—中药学]