基质金属蛋白酶及其抑制因子与组织纤维化的研究进展  

Advances of study on efeects of matrix metalloproteinases and its tissue inhibitors on tissue fibrosis

作　　者：侯元婕[1] 薛克修[1] 

机构地区：[1]新乡医学院三附院外科,河南新乡453003

出　　处：《新乡医学院学报》2006年第2期204-206,共3页Journal of Xinxiang Medical University

基　　金：河南省科技攻关项目(编号:0524410057)

摘　　要：目的探讨基质金属蛋白酶及其抑制因子与组织纤维化的关系。方法检索国内外相关的文献资料。结果组织纤维化基本特征是细胞外基质过度沉积和组织结构改建,而ECM降解减少是导致其过度沉积的主要原因之一,基质金属蛋白酶及其基质金属蛋白酶抑制因子是降解过程中主要调节因素。结论基质金属蛋白酶及其抑制因子在组织纤维化发生、发展及其临床治疗具有重要意义,有待于进一步探讨。Objective To discuss the relationship between matrix metalloproteinases and its tissue inhibitors and tissue fibrosis. Methods The related internal and external literatures were retrieved. Results The basic character of tissue fibrosis is that extra cellular matrix （ECM） excessively deposit and tissue structure is rebuilt, and the decrease of ECM＇s degradation is one of main reasons that lead to the excessive deposit. Matrix metalloproteinases （MMPs） and tissue inhibitors of metalloproteinases （TIMPs） are main regulator of degradation of ECM proteins. Concision The MMPs and TIMPs have very important significance in occurrence, development and clinical therapy of tissue fibrosis, they need further research.

关 键 词：基质金属蛋白酶 基质金属蛋白酶组织抑制因子 细胞外基质 纤维化 

分 类 号：R556[医药卫生—血液循环系统疾病]