氟尿嘧啶用于人乳头状瘤病毒高危型感染早期干预治疗  

Early Intervening Treatment of High Risk Human Papilloma Virus Infection with Fluorouracil

作　　者：李伟[1] 黄晓园[1] 庄亮[1] 王薇[1] 朱涛[1] 李箫[1] 马丁[1] 

机构地区：[1]华中科技大学同济医学院附属同济医院肿瘤生物医学中心,武汉430030

出　　处：《医药导报》2006年第4期306-308,共3页Herald of Medicine

基　　金：国家自然科学基金资助项目(基金编号:30271358)

摘　　要：目的探讨应用氟尿嘧啶(5-FU)进行宫颈乳头状瘤病毒(HPV)高危型感染早期干预治疗的疗效。方法采用液基薄层细胞学检测(TCT)和HPV DNA分型检测进行宫颈HPV高危型感染的筛查,选取细胞学异常和HPV高危型阳性6个月未自然转阴的宫颈上皮内瘤变(C IN)Ⅰ级患者50例,随机分为治疗组和对照组各25例。治疗组给予氟尿嘧啶可吸收缓释药膜的局部干预治疗。对照组未进行任何干预治疗。治疗过程中定期复查TCT及HPV DNA水平。结果治疗组HPV病毒负荷量呈明显的下降趋势,并于治疗第3个月时病毒转阴5例(20.0%),第6个月时C INⅠ级患者出现病理逆转13例(52.0%),对照组仅出现逆转2例(8.0%),两组缓解率比较差异有显著性(P<0.05)。结论对于C INⅠ级的HPV高危型感染患者,采用氟尿嘧啶可吸收缓释药膜治疗,可促使HPV病毒负荷量的降低,甚至清除。Objective To approach the therapeutic effectiveness of early intervening treatment of high risk human papilloma virus（HPV） infection of cervix uteri with fluorouracil （5-FU）. Methods High risk HPV infection of the cervix was screened out with the thinprep cytological test （TCT） and hybrid capture Ⅱ （ HC- Ⅱ ） . 50 cases of Grade Ⅰ cervical intraepithelial neoplasia（ CIN- Ⅰ ） with cytological abnormalies and high risk HPV infection lasting 6 months were chosen and randomly divided into 2 equal groups, the control group and the trial group. Patients of the trial group were subjected to local intervening treatment with absorbable and sustained-release 5=FU medicine membranes while patients of the control group received no intervening treatment. TCT and determination of the HPV DNA levels were repeated at regular intervals during the course of treatment. Results Distinct downward trend of the loading dose of HPV was shown in patients of the trial group and the virus disappeared in 5 patients（20.0 % ） during the 3^th month of treatment. In the 6^th month of treatment, pathological reversion was demonstrated in 13 patients（52.0 % ） and only 2 cases （8.0 % ）of the trial group and control group, respectively（P 〈 0.05 ）. Conclusion Treatment of CIN- Ⅰ patients with high risk HPV infection with absorbable and sustained- release 5-FU medicine membranes was shown to result in decrement of the loading dose of HPV or even eradication of the virus.

关 键 词：氟尿嘧啶 缓释药膜 宫颈癌 人乳头状瘤病毒 

分 类 号：R978.7[医药卫生—药品] R711.74[医药卫生—药学]