阿奇霉素注射用灭菌粉末治疗呼吸系统中重度感染30例  

Treatment of 30 Cases of Moderate to Severe Infections of the Respirarory System with Sterilized Powder of Azithromycin for Injection

作　　者：谢永宏[1] 金发光[1] 

机构地区：[1]第四军医大学唐都医院呼吸科,西安710038

出　　处：《医药导报》2006年第4期308-311,共4页Herald of Medicine

摘　　要：目的评价阿奇霉素注射用灭菌粉末(派奇)对呼吸系统中、重度感染的疗效与安全性。方法采用随机对照研究方法,将60例中、重度呼吸系统感染患者随机分为两组。治疗组30例,用阿奇霉素注射用灭菌粉末250 mg加入5%葡萄糖注射液500 mL,静脉滴注,qd,疗程5 d。对照组用红霉素注射用灭菌粉末1.5 g加入5%葡萄糖注射液500 mL,静脉滴注,qd,疗程5 d。结果治疗组有效率和痊愈率分别为93.3%和83.3%,对照组为86.7%和66.7%(均P>0.05)。治疗组不良反应发生率为16.7%,显著低于对照组的36.7%(P<0.05)。结论阿奇霉素注射用灭菌粉末对呼吸系统中、重度感染疗效好且不良反应低。Objective To assess the therapeutic effectiveness and safety rate of the sterilized powder of azithromycin for injection in the treatment of moderate to severe infections of the respiratory system. Methods 60 patients with moderate to severe infections of the respiratory system were randomly divided into two equal groups, the trial group and control group. Patients of the trial group were given each 250 mg of the sterilized powder of azithromycin for injection in 500 mL of 5 % glucose solution administered by IV instillation q. d.. Patients of the control group were given each 1.5 g of erythromycin in 500 mL of 5 % glucose solution administered by IV instillation q. d. as well. The course of treatment in both groups lasted 5 days. Results The effective rate and cure rate in patients of the trial group were 93.3 % and 83.3 %, respectively, while those in patients of the control group were 86.7 % and 66.7 % ,respectively. The incidence of adverse reactions in the patients of the trial group was 16.7 %, strikingly lower than that （36.7 % ） in patients of the control group（ P 〈 0.05）. Conclusion The sterilized powder of azithromycin for injection was shown to be very effective in the treatment of moderate to severe infections of the respiratory system and its incidence of adverse reactions was low.

关 键 词：阿奇霉素 红霉素 感染 呼吸道 

分 类 号：R969.4[医药卫生—药理学]