米氏消除药物血管外给药血药浓度的数值解  

Plasma Concentration of Drugs Obeying the Michaelis-Menten Clearance Kinetics in the Case of Extravascular Administration

作　　者：苏银法[1] 杜乐燕[2] 

机构地区：[1]浙江省温州市第二人民医院临床药学科,325000 [2]温州医学院附属第一医院呼吸科,325000

出　　处：《医药导报》2006年第4期357-359,共3页Herald of Medicine

基　　金：温州市科技局资助项目(基金编号:Y2003-A075)

摘　　要：目的获得(一级并行)米氏消除药物血管外给药时的血药浓度近似值。方法根据四阶Runge-Kutta算法,采用Excel软件编写基于药动学参数的血药浓度近似解表格程序。结果通过实例演示,可以输出第n周期(或稳态)第s次血管外给药后每间隔0.005 h的预期血药浓度。结论该法是(一级并行)米氏消除药物血管外给药动力学方程的一种可靠的数值解法。Objective To establish a numerical method for the assay of plasma concentrations of drugs obeying the parallel first order and Michaelis-Menten clearance kinetics in the case of extravascular administration. Methods According to the fourstage Runge-Kutta algorithm, we used Microsoft Excel to make a program based on the pharmacokinetic parameters. Results The Microsoft Excel spreadsheet displayed plasma concentrations at 0.005 hour intervals after the administration. Conclusion The algorithm was shown to be a reliable numerical method that may be used to obtain data of plasma concentrations of drugs obeying parallel first order and Michaelis-Menten clearance kinetics in the case of extravascular administration.

关 键 词：血管外给药 米氏消除 Runge-Kutta算法 血药浓度 

分 类 号：R969.1[医药卫生—药理学]