μ-阿片受体参与介导丘脑中央下核内吗啡抑制的诱发性炎性痛  

Contribution of μ-opioid Receptor in the Thalamic Nucleus Submedius to Morphine-evoked Antinociception in Formalin-test Rat

作　　者：杨智杰[1] 秦达念[1] 

机构地区：[1]汕头大学医学院生理学教研室

出　　处：《汕头大学医学院学报》2006年第1期19-22,共4页Journal of Shantou University Medical College

摘　　要：目的:探明丘脑中央下核(Sm)内给予吗啡诱发大鼠炎性痛抑制效应的阿片受体类型。方法:建立福尔马林诱发炎性疼痛的动物模型,神经核团内微量注射拟定药物,采用福尔马林试验人工评分法进行疼痛分数评价。结果:福尔马林诱发的晚时相反应(炎性持续痛)的疼痛分数值可因单侧Sm内供给吗啡(5.0μg,0.5μL)后明显变小(抑制作用),μ-阿片受体拮抗剂(-βFNA,0.1μg)可完全翻转吗啡诱发的抑制效应,δ-阿片受体拮抗剂(naltrindole,0.3μg)和κ-阿片受体拮抗剂(nor-binal-torphimine,0.1μg)均不能取消吗啡产生的抑制效应。结论:Sm内给予吗啡产生的抗炎性痛效应是由μ-阿片受体介导的。Objective： To characterize the roles of various opioid receptors involved in thalamic nucleus submedius（Sm） morphine-evoked antinociception in the formalin-test rat. Methods： Formahn（5%, 50 μL）was subcutaneously injected into the rat hindpaw and drugs were microinjected into the submedius, the formalin-evoked nociceptive behaviors were evaluated as pain score by manual methods. Results： Morphine（5.0 μg）microinjected unilaterally into Sm produced significantly an inhibition on pain score, and these could be blocked by pre-administration of selective μ-opioid receptor antagonist（β-funaltrexamine hydrochloride, 0. 1 μg）, but the selective κ-receptor antagonist（naltrindole）and selective κ- receptor antagonist（nor-binaltorphimine）had no effects. Conclusion： The μ-opioid receptor is involved in the Sm morphine-evoked antinociception in the formalin test rat.

关 键 词：丘脑中央下核 吗啡 阿片受体亚型 疼痛分数 福尔马林试验 大鼠 

分 类 号：Q426[生物学—神经生物学]