SEC对胶质瘤的体内杀伤及其联合放射治疗的研究  

Study of anti-glioma of SEC in vivo and in combination with radiotherapy for glioma

作　　者：王凡[1] 黄强[2] 周丽英[2] 

机构地区：[1]安徽医科大学第一附属医院肿瘤放疗科,合肥230022 [2]苏州大学第二附属医院神经外科,苏州215000

出　　处：《中国免疫学杂志》2006年第3期224-226,共3页Chinese Journal of Immunology

基　　金：安徽省教育厅自然科学计划基金资助(No.2003KJ218)

摘　　要：目的:观察SEC活化的淋巴细胞对胶质瘤的体内杀伤作用,并观察SEC联合手术、放疗、化疗对胶质瘤的治疗效果。方法:选用T、B淋巴细胞联合免疫缺陷的SCID小鼠,通过建立荷瘤动物模型及HuPBL-SCID免疫嵌合模型,观察肿瘤生长曲线,荷瘤小鼠生存曲线。30例胶质瘤患者,均经手术切除、放疗、化疗,随机分对照组,处理1组(全身应用SEC),处理2组(局部应用经SEC活化的淋巴细胞)。结合MRI片观察疗效。结果:生长曲线显示:A组、C组、B组对胶质瘤的抑制率分别为58·5%、46·2%和36·3%。生存期曲线显示:对照组(D组)小鼠于第27天开始出现死亡,至第40天全部死亡,而A组小鼠在40天才开始出现死亡,其中有50%的小鼠到观察的最后时期(60天)仍生存良好。临床资料显示对照组有效率为40%,处理1组及处理2组有效率为50%和62·5%。结论:SEC在胶质瘤移植后的人源化免疫嵌合模型(SCID/HuPBL/SHG44)中显示出强大的抗胶质瘤作用。SEC与手术、放疗、化疗结合,能明显提高临床病人的疗效。Objective：To observe the anti-glioma effects of lymphocyte activated by SEC in vivo and probe into therapy effects of SEC combing with operation,radiotherapy and chemotherapy. Methods：Experiment animals were SCID mice. With establishing animal model of glioma xenografted and immunity chimeric model of HuPBL-SCID,we observed the growth curve, survive time. With having operation,radiotherapy and chemotherapy,30 patients suffering from glioma were divided into control group,handle group 1 and 2, and then results were analyzed with MRI. Results：Growth curve shows：A, C and B group produced different suppress against glioma and its suppress rate were 58.5% ,46. 2% and 36. 3%. The first death occurred at the 17th day in control group mice and all mice deaded at the 40th day. Contrasting to this,the first death occurred at the 40th day and 50% mice still were alive in group A until the day that experiment has just finished （60 day）. Clinical material showed ：The rate of effect（ CR and PR） in control group was 40%, while the rate of effects was 50% in handle group 1 and 62.5% in handle group 2. Concluslon：SEC has extramaly potent anti-tumor activity against glioma. SEC combined with operation, radiatherapy and chemotherapy can raise treatment effect in patients with glioma.

关 键 词：超抗原 胶质瘤 重症联合免疫缺陷型小鼠 综合治疗 

分 类 号：R392[医药卫生—免疫学] R730.264[医药卫生—基础医学]