慢性乙型肝炎患者外周血T细胞KIR表达研究  

The expression of killer inhibitory receptors on T lymphocytes in chronic hepatitis B

作　　者：王沂芹[1] 柏健鹰[2] 傅晓岚[3] 王惠明[1] 赵婷婷[1] 徐文越[1] 吴玉章[1] 

机构地区：[1]中国人民解放军第三军医大学基础部全军免疫研究所,重庆400038 [2]中国人民解放军第三军医大学新桥医院消化科,重庆400037 [3]中国人民解放军第三军医大学中心实验室,重庆400038

出　　处：《中国免疫学杂志》2006年第3期257-259,共3页Chinese Journal of Immunology

基　　金：国家重点基础研究发展规划项目(973计划)(2001CB510001);国家自然科学基金重大项目(30490241)

摘　　要：目的:检测慢性乙型肝炎患者外周血T细胞表面KIR的表达情况。方法:采用三色流式细胞术检测慢性乙型肝炎患者外周血CD4+T细胞和CD8highT细胞表面KIR分子表达,并与正常外周血比较。结果:慢性乙型肝炎患者外周血中CD8highT细胞KIR表达明显高于对照组CD8highT细胞。正常外周血CD4+T细胞几乎不表达KIR,慢性乙型肝炎患者外周血中CD4+T细胞表达KIR。结论:慢性乙型肝炎患者T细胞表面KIR表达明显增加。Objective：To study the expression of killer inhibitory receptors（KIR） on T lymphocytes in chronic hepatitis B patients. Methods：KIR expressed on ,the surface of T lymphocytes were determined by threo-colour flow cytometry in chronic hepatitis B patients,and the results were compared with those of normal peripheral blood. Results：The expression of KIR on CD8^high T lymphocytes in chronic hepatitis B patients was 4. 30% ± 2.02%, which was higher than that in normal peripheral blood （P 〈 0. 05 ）. KIR was rarely detected on CD4^＋ T lymphocytes in normal peripheral blood, but the expression of KIR on CD4^＋ T lymphocytes in chronic hepatitis B patients was 1.55% ± 0. 71%. Conclusion：The expressions of KIR on T lymphocytes are increased in chronic hepatitis B.

关 键 词：慢性乙型肝炎 T淋巴细胞 杀伤细胞抑制性受体 

分 类 号：R512.62[医药卫生—内科学]